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127-60-6

127-60-6 Structure

127-60-6 Structure
IdentificationBack Directory
[Name]

acediasulfone sodium
[CAS]

127-60-6
[Synonyms]

acediasulfone sodium
acediasulfone sodium USP/EP/BP
N-[4-[(4-Aminophenyl)sulfonyl]phenyl]glycine sodium salt
[EINECS(EC#)]

204-852-6
[Molecular Formula]

C14H15N2NaO4S
[MDL Number]

MFCD22493325
[MOL File]

127-60-6.mol
[Molecular Weight]

330.33
Hazard InformationBack Directory
[Originator]

Solfone ,Bracco
[Manufacturing Process]

24.8 g of 4,4'-diaminodiphenyl sulfone, 150 g of methyl chloroacetate and 150 ml of ethanol are refluxed together and refluxed for 24 hours. The alcohol and excess methyl chloroacetate are then distilled off on a steam bath under reduced pressure. The residue consisting of the hydrochloride salt of 4-amino- 4'-(carbomethoxymethylamino)diphenyl sulfone is mixed with of alcoholic solution containing 2.5 g lithium hydroxide and refluxed for 4 hours on the steam bath. Most of the alcohol is removed by distillation and the residual lithium salt of 4-amino-4'-(carboxymethylamino)diphenyl sulfone taken up water. The solution is filtered and dilute HCl added until no more separation occurs. The 4-amino-4'-(carboxymethylamino)diphenyl sulfone thus obtained is collected and dried.
The sodium salt of 4-amino-4'-(carboxymethylamino)diphenyl sulfone is prepared by dissolving the free acid in an aqueous solution containing one equivalent of sodium hydroxide and evaporating the solution to dryness in vacuo.
[Therapeutic Function]

Antibacterial
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