| Identification | Back Directory | [Name]
acediasulfone sodium | [CAS]
127-60-6 | [Synonyms]
acediasulfone sodium
acediasulfone sodium USP/EP/BP
N-[4-[(4-Aminophenyl)sulfonyl]phenyl]glycine sodium salt | [EINECS(EC#)]
204-852-6 | [Molecular Formula]
C14H15N2NaO4S | [MDL Number]
MFCD22493325 | [MOL File]
127-60-6.mol | [Molecular Weight]
330.33 |
| Hazard Information | Back Directory | [Originator]
Solfone ,Bracco | [Manufacturing Process]
24.8 g of 4,4'-diaminodiphenyl sulfone, 150 g of methyl chloroacetate and 150
ml of ethanol are refluxed together and refluxed for 24 hours. The alcohol and
excess methyl chloroacetate are then distilled off on a steam bath under
reduced pressure. The residue consisting of the hydrochloride salt of 4-amino-
4'-(carbomethoxymethylamino)diphenyl sulfone is mixed with of alcoholic
solution containing 2.5 g lithium hydroxide and refluxed for 4 hours on the
steam bath. Most of the alcohol is removed by distillation and the residual
lithium salt of 4-amino-4'-(carboxymethylamino)diphenyl sulfone taken up
water. The solution is filtered and dilute HCl added until no more separation
occurs. The 4-amino-4'-(carboxymethylamino)diphenyl sulfone thus obtained
is collected and dried.
The sodium salt of 4-amino-4'-(carboxymethylamino)diphenyl sulfone is
prepared by dissolving the free acid in an aqueous solution containing one
equivalent of sodium hydroxide and evaporating the solution to dryness in
vacuo. | [Therapeutic Function]
Antibacterial |
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