| Identification | Back Directory | [Name]
NQ301 | [CAS]
130089-98-4 | [Synonyms]
NQ301
NQ 301; NQ-301
NQ301 >=98% (HPLC)
NQ301 - Compound 211
2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione
2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione
1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro- | [Molecular Formula]
C18H12ClNO3 | [MDL Number]
MFCD00559986 | [MOL File]
130089-98-4.mol | [Molecular Weight]
325.75 |
| Chemical Properties | Back Directory | [Melting point ]
241-243 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
476.8±45.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO:10.0(Max Conc. mg/mL);30.7(Max Conc. mM) | [form ]
powder | [pka]
-5.25±0.20(Predicted) | [color ]
faint red to dark red |
| Hazard Information | Back Directory | [Uses]
NQ 301 possess antiplatelet effect, making it an antithrombotic agent. It significantly inhibited the collagen-?, thrombin-?, arachidonic acid-?, thapsigargin- and calcium ionophore A23187-?induced aggregation of washed human platelets. | [Biochem/physiol Actions]
NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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