| Identification | Back Directory | [Name]
Efaproxiral | [CAS]
131179-95-8 | [Synonyms]
faproxiral
Efaproxiral
EFAPROXIRALUM
Efaproxiral free acid
EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL
2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid
2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid
Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl- | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C20H23NO4 | [MDL Number]
MFCD00899086 | [MOL File]
131179-95-8.mol | [Molecular Weight]
341.4 |
| Chemical Properties | Back Directory | [Melting point ]
48-50°C | [Boiling point ]
554.5±50.0 °C(Predicted) | [density ]
1.202±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.26±0.10(Predicted) | [color ]
Off-White to Tan |
| Hazard Information | Back Directory | [Description]
Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue.1 In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model.2 Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg.3 It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.4 | [Chemical Properties]
Off-White to Tan Solid | [Uses]
Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer). |
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