| Identification | Back Directory | [Name]
Leniolisib | [CAS]
1354690-24-6 | [Synonyms]
CS-2818
CDZ 173
Leniolisib
leniolisib(CDZ 173)
CDZ173;CDZ-173;CDZ 173
1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]- | [Molecular Formula]
C21H25F3N6O2 | [MOL File]
1354690-24-6.mol | [Molecular Weight]
450.46 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:71.67(Max Conc. mg/mL);159.09(Max Conc. mM)
Ethanol:16.5(Max Conc. mg/mL);36.63(Max Conc. mM) | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Biological Activity]
Leniolisib (CDZ 173) is a potent and selective PI3Kδ inhibitor with IC50s of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. | [target]
| Target | Value | PI3Kδ
(Cell-free assay) | 0.011 μM | PI3Kα
(Cell-free assay) | 0.244 μM | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PI3Kβ
(Cell-free assay) 0.424 μM | DNA-PK
() | 0.88 μM | DNA-PK
(Cell-free assay) | 0.88 μM |
| [storage]
Store at -20°C |
|
| Company Name: |
Twochem Co.Ltd
|
| Tel: |
021-58111628 15800915896 |
| Website: |
http://www.twochem.com |
|