| Identification | Back Directory | [Name]
(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one | [CAS]
1448867-41-1 | [Synonyms]
CS-2613
CS-2787
HDM-201
NVP-HDM201
Siremadlin
Siremadlin (NVP-HDM201)
NVP-HDM201;HDM-201;NVP-HDM-201
HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201
(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one
Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)- | [Molecular Formula]
C26H24Cl2N6O4 | [MDL Number]
MFCD30502893 | [MOL File]
1448867-41-1.mol | [Molecular Weight]
555.41 |
| Chemical Properties | Back Directory | [Boiling point ]
736.5±70.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 56.75 mg/mL (102.18 mM) | [pka]
1.33±0.29(Predicted) |
| Hazard Information | Back Directory | [Uses]
Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies. the safety profile of Siremadlin did not differ significantly between tumor types and treatment regimens. |
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