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186544-26-3

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186544-26-3 Structure

186544-26-3 Structure
IdentificationBack Directory
[Name]

LY 344864
[CAS]

186544-26-3
[Synonyms]

CS-660
Y344864
LY 344864
LY344864 HCL
LY344864;LY-344864
LY 344864 hydrochloride
(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide
Benzamide, N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-
(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride
[Molecular Formula]

C21H22FN3O
[MDL Number]

MFCD07772184
[MOL File]

186544-26-3.mol
[Molecular Weight]

351.42
Chemical PropertiesBack Directory
[Boiling point ]

471.9±45.0 °C(Predicted)
[density ]

1.28±0.1 g/cm3(Predicted)
[storage temp. ]

Store at +4°C
[pka]

14.12±0.40(Predicted)
Hazard InformationBack Directory
[Biological Activity]

Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
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