| Identification | Back Directory | [Name]
2,5-OXAZOLIDINEDIONE | [CAS]
2185-00-4 | [Synonyms]
GLY-NCA
L-Gly-NCA
2,5-OXAZOLIDINEDIONE
oxazolidine-2,5-dione
2,5-Oxazolidinedione 98%
1,3-oxazolidine-2,5-dione
GLYCINE-N-CARBOXYANHYDRIDE
N-Carboxyglycine anhydride | [EINECS(EC#)]
218-570-6 | [Molecular Formula]
C3H3NO3 | [MDL Number]
MFCD00075543 | [MOL File]
2185-00-4.mol | [Molecular Weight]
101.06 |
| Hazard Information | Back Directory | [Preparation]
Into a suspension of finely ground glycine (15 g) in dry dioxane (750 mL), phosgene was introduced in a fine stream at 45–50 °C with efficient agitation. A clear solution was obtained after 5 h. This solution was filtered to remove unreacted glycine (1.7 g), and the dioxane was then removed under reduced pressure at a temperature below 40 °C with protection from moisture. The residue was treated with dry diethyl ether (100 mL), and the crystals of 2,5-oxazolidinedione were collected by filtration and dried over P2O5 in a vacuum desiccator. The crude product so obtained, 16 g (89%), was recrystallized from ethyl acetate/petroleum ether to yield 14.3 g (77.2%) of pure material, which showed no melting point because of polymerization. | [Preparation]
Phosgene was passed in a fine stream into a suspension of finely ground glycine (15 g) in dry dioxane (750 mL) at 45–50 ℃ with efficient agitation. A clear solution was obtained after 5 h. This solution was filtered to remove unreacted glycine (1.7 g), and the dioxane was then removed under reduced pressure at a temperature below 40 ℃ under exclusion of moisture. The residue was treated with dry diethyl ether (100 mL), and the crystals of 2,5-oxazolidinedione were collected by filtration and dried over P2O5 in a vacuum desiccator. The crude product thus obtained, 16 g (89%), was recrystallized from ethyl acetate/petroleum ether to yield 14.3 g (77.2%) of pure material, which showed no melting point because of polymerization. |
|
|