| Identification | Back Directory | [Name]
CP-547632 | [CAS]
252003-65-9 | [Synonyms]
CS-1957
CP-547632
CP-547632(CP 547632)
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami
3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide
3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
4-Isothiazolecarboxamide, 3-((4-bromo-2,6-difluorophenyl)methoxy)-5-((((4-(1-pyrrolidinyl)butyl)amino)carbonyl)amino)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C20H24BrF2N5O3S | [MDL Number]
MFCD07772279 | [MOL File]
252003-65-9.mol | [Molecular Weight]
532.4 |
| Chemical Properties | Back Directory | [Boiling point ]
548.6±50.0 °C(Predicted) | [density ]
1.532 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: 94 mM | [form ]
A solid | [pka]
12.50±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice. |
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