| Identification | Back Directory | [Name]
1a,1b-dihomoprostaglandin E2 | [CAS]
26198-80-1 | [Synonyms]
1a,1b-dihomoprostaglandin E2
7-Nonenoic acid, 9-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-5-oxocyclopentyl]-, (7Z)- | [Molecular Formula]
C22H36O5 | [MOL File]
26198-80-1.mol | [Molecular Weight]
380.52 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid .1 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid (AA; ).2 This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.2 | [storage]
Store at -20°C | [References]
1. Tobias, L.D., Vane, F.M., and Paulsrud, J.R. The biosynthesis of 1a,1b-dihomo-PGE2 and 1a,1b-dihomo-PGF2a from 7,10,13,16-docosatetraenoic acid by an acetone-pentane powder of sheep vesicular gland microsomes Prostaglandins 10(3),443-468(1975).
2. Harkewicz, R., Fahy, E., Andreyev, A., et al. Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells J. Biol. Chem. 282(5),2899-2910(2007). |
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