| Identification | Back Directory | [Name]
3-METHYL-1H-INDAZOLE | [CAS]
3176-62-3 | [Synonyms]
3-METHYL-1H-INDAZOLE
1H-Indazole, 3-methyl- | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C8H8N2 | [MDL Number]
MFCD00601361 | [MOL File]
3176-62-3.mol | [Molecular Weight]
132.16 |
| Chemical Properties | Back Directory | [Melting point ]
113°C | [Boiling point ]
234.08°C (rough estimate) | [density ]
1.1083 (rough estimate) | [refractive index ]
1.6013 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.39±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
3-Methyl-1H-indazole is a heterocyclic alkyl compound containing nitrogen and three methyl groups. It is used as an intermediate in the synthesis of other compounds. It has been shown to have anti-inflammatory properties in vitro. It also inhibits neutrophil chemotaxis and may be used to treat inflammatory diseases such as trigeminal neuralgia or heart disease. 3-Methyl-1H-indazole has also been shown to inhibit histamine H3 receptor activity, which may account for its effects on eye diseases and bladder cancer. | [Uses]
3-Methyl-1H-indazole is an intermediate compound. It can be used as an organic synthesis reagent for the preparation of 3-methyl-1H-indazol-5-amine and 3-methyl-5-nitro-1H-indazole compounds. In addition, the 3-Methyl-1H-indazole derivatives (1a-1d and 2a-2d) have antimicrobial effects, both having antibacterial activity against Bacillus subtilis and Escherichia coli[1]. | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 25, p. 1817, 1988 DOI: 10.1002/jhet.5570250641
Synthesis, p. 982, 1984 | [References]
[1] FARRUKH SHAIKH. Synthesis and evaluation of antibacterial activity of novel 3-methyl-1H-indazole derivatives[J]. Intelligent Pharmacy, 2024. DOI:10.1016/j.ipha.2023.09.003. |
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