| Identification | Back Directory | [Name]
FLAVOKAVAIN A(P) | [CAS]
37951-13-6 | [Synonyms]
Flavokavain A
FLAVOKAVAIN A(P)
(E)-Flavokawain A
(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
2-Propen-1-one,1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-, (2E)- | [Molecular Formula]
C18H18O5 | [MOL File]
37951-13-6.mol | [Molecular Weight]
314.33 |
| Chemical Properties | Back Directory | [Melting point ]
113-114℃ | [Boiling point ]
529.9±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | [form ]
A solid | [pka]
6.88±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Flavokawain A is a?chalcone found in the kava plant. It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway. Furthermore, natural chalcones have been?implicated as lead compounds for developing dual inhibitors against?histone deacetylase enzymes (HDACs)?and NF-κB. | [Definition]
ChEBI:Flavokawain A is a member of chalcones. | [storage]
4°C, protect from light |
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