| Identification | Back Directory | [Name]
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 | [CAS]
39024-57-2 | [Synonyms]
LHG-17
[Leu15]-HG-17
[LEU15]-GASTRIN I
gastrin I, human Leu15
(LEU15)-GASTRIN I (HUMAN)
(Leu15)-Gastrin-17 I (human)
[Leucine15]-Little gastrin I
[15-leucine]gastrin I, human
(15-LEUCINE) HUMAN GASTRIN I
leu(15)-gastrinheptadecapeptid
gastrin heptadecapeptide, Leu(15)-
[Leucine15]-Gastrin I heptadecapeptide
[15-leucine]-gastrin i, human heptadecapeptide
18-(5-Oxo-L-proline)-22-L-leucine-32-L-leucine-18-34-gastrinI【pig】
18-34-Gastrin I (pig), 18-(5-oxo-l-proline)-22-l-leucine-32-l-leucine-
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
H-PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
(Leu15)-Gastrin-17 I (huMan), (Pyr18,Leu22,Leu32)-Gastrin I (18-34) (porcine)
[18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human
Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2
(Leu15)-Gastrin I (huMan)
(Leu15)-Gastrin-17 I (huMan), (Pyr18,Leu22,Leu32)-Gastrin I (18-34) (porcine)
5-Oxo-L-Pro-Gly-L-Pro-L-Trp-L-Leu-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Leu-L-Asp-L-Phe-NH2
L-Phenylalaninamide, 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-α-aspartyl-
[15-Leucine]-Gastrin I, human heptadecapeptide, [Leu15]-Gastrin I, human, [Leu15]-HG-17, [Leucine15]-Gastrin I heptadecapeptide, [Leucine15]-Little gastrin I, LHG-17, [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human | [EINECS(EC#)]
254-250-2 | [Molecular Formula]
C98H126N20O31 | [MDL Number]
MFCD00076502 | [MOL File]
39024-57-2.mol | [Molecular Weight]
2080.2 |
| Chemical Properties | Back Directory | [Boiling point ]
2368.8±65.0 °C(Predicted) | [density ]
1.400±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [pka]
4.20±0.10(Predicted) | [BRN ]
5227423 | [Sequence]
Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2 |
| Hazard Information | Back Directory | [Uses]
Gastrin has been used:
- as a medium supplement establish enteroid cultures
- as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium, human minigut medium to establish the growth of crypts.
| [General Description]
GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2. G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin. Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR). Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin. | [Biochem/physiol Actions]
Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity. |
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