| Identification | Back Directory | [Name]
N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide | [CAS]
448944-47-6 | [Synonyms]
melitane
melitane/acetylhexapeptide-1
peptides Acetyl Hexapeptide-1
N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide
L-Tryptophanamide, N-acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-
N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide USP/EP/BP | [Molecular Formula]
C43H59N13O7 | [MOL File]
448944-47-6.mol | [Molecular Weight]
870.01 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [pka]
13.36±0.46(Predicted) | [InChIKey]
WPIQUSRULDNCKM-IFSWANACSA-N | [SMILES]
C(N)(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1N=CNC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCCC)NC(C)=O |
| Hazard Information | Back Directory | [Description]
Acetyl hexapeptide-1 is a synthetic peptide composed of the amino acids alanine, arginine, histidine, leucine, phenylalanine and tryptophan. It helps skin better defend itself from environmental aggressors by virtue of a calming effect. This peptide can also help promote a visibly more even skin tone by playing a role in how melanin moves through skin.
Acetyl Hexapeptide-1 is a bit of a special snowflake among peptides as it's not a wrinkle-smoothing, anti-aging active like most of the other ones but it can stimulate pigmentation and melanin production (by interacting with a skin cell receptor called MC1R).
As melanin not only gives the skin its nice tanned color but also works as a natural protection factor, Acetyl Hexapeptide-1, aka Melitane does the same. It not only boosts a natural or an artificial tan but gives extra protection against UV-induced DNA and free radical damage and protects the skin against UV-caused redness. | [Application]
Acetyl Hexapeptide-1 works as a bio-α-MSH peptide analog. It stimulates hair pigmentation, darkens hair and reverses the gray hair process. It also can help repair DNA damage caused by UV exposure and reduce the skin erythema. | [Definition]
Acetyl Hexapeptide-1 is the reaction product of Alanine, arginine, histidine, leucine, phenylalanine and tryptophane hexapeptide with acetic acid. It activates the regulation of melanin synthesis, relating the protection of natural light and inflammatory regulator. | [benefits]
Acetyl Hexapeptide-1has affinity to MC1-R, which is a biomimeticpeptide simulating a-MSH, promote melaninproduction by combining with MC1-R,lt alsopromotes transfer melanin from melanocytes tokeratinocytes, coloring the hair.Its recommended dosage is 0.1~5%. | [Mechanism of action]
Acetyl Hexapeptide-1 is a novel acetyl hexapeptide, which mainly acts on a presynaptic membrane and a postsynaptic membrane to reduce the transmission of neurotransmitters and reduce the shrinkage of muscles, thereby achieving the purpose of smoothing expression lines and the addition of acetyl hexapeptide-1 to cosmetics does not cause the instability of the cosmetic properties. |
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