| Identification | Back Directory | [Name]
O7,O7'-didemethylcycleanine | [CAS]
477-62-3 | [Synonyms]
Isobebeerin
Isochondodendrin
Einecs 207-517-2
(+)-Isobebeerine
Isochondodendrine
Isochondrodendrin
D-Isochondodendrine
D-Isochondrodendrine
(R,R)-Isochondodendrine
O7,O7'-didemethylcycleanine
7-O,7'-O-Didemethylcycleanine
Cycleanine, o7,o7'-didemethyl- (9ci)
Cycleanine, o(sup 7),o(sup 7')-didemethyl-
(1R,1'R)-2,2'-Dimethyl-6,6'-dimethoxy-7,18:11',18-diseco-8,18:12',18-dicyclotubocuraran-7,7'-diol
8,11:20,23-Dietheno-1H,12H-[1,10]dioxacyclooctadecino[2,3,4-ij:11,12,13-i'j']diisoquinoline-6,18-diol, 2,3,12a,13,14,15,24,24a-octahydro-5,17-dimethoxy-1,13-dimethyl-, (12aR,24aR)- | [EINECS(EC#)]
207-517-2 | [Molecular Formula]
C36H38N2O6 | [MDL Number]
MFCD01734108 | [MOL File]
477-62-3.mol | [Molecular Weight]
594.7 |
| Chemical Properties | Back Directory | [Melting point ]
316 °C (decomp) | [alpha ]
D20 -29° (c = 1.3 in chloroform) | [Boiling point ]
689.0±55.0 °C(Predicted) | [density ]
1.239±0.06 g/cm3(Predicted) | [pka]
9.10±0.20(Predicted) |
| Hazard Information | Back Directory | [Definition]
ChEBI: Isochondrodendrine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid. | [Biological Activity]
Isochondrodendrine (Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloids isolated from Isolona ghesquiereina. It has strong anti-plasmid activity against Plasmodium falciparum. | [in vivo]
Isochondrodendrine has strong in vitro antiplasmodial activity against the chloroquine resistant strain FMC29 of Plasmodium falciparum . Toxicity observed is 50 to 100 fold greater towards Plasmodium falciparum than cultured L6 cells. | [target]
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