| Identification | Back Directory | [Name]
licarin A | [CAS]
51020-86-1 | [Synonyms]
licarin A
NSC 370989
4-[(2S)-2,3-Dihydro-7-methoxy-3β-methyl-5-[(E)-1-propenyl]benzofuran-2-yl]-2-methoxyphenol
Phenol, 4-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-propen-1-yl-2-benzofuranyl]-2-methoxy- | [Molecular Formula]
C20H22O4 | [MDL Number]
MFCD20260801 | [MOL File]
51020-86-1.mol | [Molecular Weight]
326.39 |
| Hazard Information | Back Directory | [Biological Activity]
Licarin A ((+)-Licarin A), which can be isolated from a variety of plants, significantly reduces dinitrophenylhydrazine-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. It has anti-allergic effect and reduces TNF-α and PGD2 production, and COX-2 expression. | [in vitro]
Licarin A is found in plants such as Aristolochia taliscana , Machilus thunbergii and Myristica fragrans , which are used as spices and in folk medicines for nervous and digestive disorders. It also exhibits anti-inflammatory effects.
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels. |
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| Company Name: |
BioBioPha Co., Ltd.
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| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
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