| Identification | Back Directory | [Name]
Isowightenon | [CAS]
68436-47-5 | [Synonyms]
Isowightenon
Isowighteone
Isowigtheone
3'-Dimethylallylgenistein
4',5,7-Trihydroxy-3'-prenylisoflavone
3'-(3-Methyl-2-butenyl)-4',5,7-trihydroxyisoflavone
4',5,7-Trihydroxy-3'-(3-methyl-2-butenyl)isoflavone
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]- | [Molecular Formula]
C20H18O5 | [MOL File]
68436-47-5.mol | [Molecular Weight]
338.35 |
| Hazard Information | Back Directory | [Uses]
Isowighteone is a natural product derivative of Genistein (G350000). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol. | [Definition]
ChEBI: Isowighteone is a member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 4' and a prenyl group at position 3'. It has been isolated from Ficus mucuso. It has a role as a plant metabolite. It is functionally related to an isoflavone. | [target]
Antifection |
|
| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
|