| Identification | Back Directory | [Name]
1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE | [CAS]
688348-25-6 | [Synonyms]
PDM 2
PDM-2;PDM2;PDM 2;688348-25-6
1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]- | [Molecular Formula]
C14H9Cl3 | [MDL Number]
MFCD08062175 | [MOL File]
688348-25-6.mol | [Molecular Weight]
283.58 |
| Chemical Properties | Back Directory | [Boiling point ]
394.2±42.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 μM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings. |
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