| Identification | More | [Name]
Terazosin hydrochloride dihydrate | [CAS]
70024-40-7 | [Synonyms]
TERAZOSIN HCL 2H2O
TERAZOSIN HYDROCHLORIDE DIHYDRATE
TERAZOSIN MONOHYDROCHLORIDE DIHYDRATE
arbonyl)-,monohydrochloride,dihydrate
Hytrinex
iperazinehcl2h2o
Terazosin HCL dihydrate
TerazosinHclC19H26C1N504
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furanyl-)carbonyl)-piperazine hydrochloride dihydrate | [EINECS(EC#)]
629-697-5 | [Molecular Formula]
C19H30ClN5O6 | [MDL Number]
MFCD00941408 | [Molecular Weight]
459.92 | [MOL File]
70024-40-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White or slightly yellow, crystalline powder. | [Melting point ]
271-274°C | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent), practically insoluble in acetone. | [form ]
neat | [CAS DataBase Reference]
70024-40-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [RTECS ]
TK8046000 | [HS Code ]
2934990002 | [Toxicity]
LD50 in male, female rats (mg/kg): 277, 293 i.v. (Fort) |
| Hazard Information | Back Directory | [Chemical Properties]
White or slightly yellow, crystalline powder. | [Uses]
analgesic, antiinflammatory | [Manufacturing Process]
To a solution of n-butanol (316 ml), water (24 ml) and N-(2-
tetrahydrofuroyl)piperazine (20 g) were added, while stirring, 4-amino-2-
chloro-6,7-dimethoxyquinazoline (22.2 g). The reaction mixture was heated to
reflux and the reflux was maintained for about 9 h. Then the reaction mixture
was cooled to room temperature and stirred at this temperature for about 10-
12 h. The crystals were collected by filtration, washed with n-BuOH and dried
in vacuo at 40-50°C to yield 40.1 g (94%) of the 1-(4-amino-6,7-dimethoxy-
2-quinazolinyl)-4-(tetrahydrofuroyl)piperazine hydrochloride dihydrate | [Therapeutic Function]
Antihypertensive |
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