| Identification | Back Directory | [Name]
HEMOGLOBIN | [CAS]
9008-02-0 | [Synonyms]
MU
HB
GST1
GTH4
GTM1
PMSA2
PSMA2
C01708
HB, BABOON
HEMOGLOBIN
HAEMOGLOBIN
Hemoglobins
O)di-mercury
METHEMOGLOBIN
Blood pigments
HEMOGLOBIN PIG
HEMOGLOBIN RAT
HEMOGLOBIN DOG
deoxyhemoglobin
HEMOGLOBIN BEEF
HEMOGLOBIN HUMAN
HEMOGLOBIN HORSE
Deoxyhemoglobins
Ferrohemoglobins
HEMOGLOBIN SHEEP
HEMOGLOBIN PIGEON
HEMOGLOBIN BOVINE
HEMOGLOBIN RABBIT
HEMIGLOBIN BOVINE
BOVINE HEMOGLOBIN
HAEMOGLOBIN, SHEEP
HEMOGLOBIN, BABOON
hemoglobin porcine
hemoglobin from rat
Hemoglobin human,Hb
-[9H]xanthene]-4'
OXYHEMOGLOBIN BOVINE
HEMOGLOBIN USP/EP/BP
Hemoglobin from Swine
Hemoglobin porcine,Hb
Hemoglobin from rat,Hb
hemoglobin from rabbit
FERROHEMOGLOBIN BOVINE
Hemoglobin,from Bovine
HemoglobinPowder,Bovine
haemoglobin(hemoglobin)
Hemoglobin from pigeon
BOVINE HEMOGLOBIN POWDER
Hemoglobin from turkey
Hemoglobin (Bovine, 2*cryst)
HEMOGLOBIN FROM BOVINE BLOOD
g/mL in acetonitrile: water)
Hemoglobin from porcine blood
HEMOGLOBIN, BOVINE ERYTHROCYTES
Hemoglobin from baboon plasma
HEMOGLOBIN: FROM BOVINE (POWDER)
HEMOGLOBIN BOVINE2xcryst. lyophil
ethyl-6-benzofuran Ethanamine &Eta
)-Methadone and Oxycodone, 250
g/mL of each component in methanol)
Fumonisin B1-13C34 solution|(25
ethyl-6-benzofuran Ethanamine-d6 &Eta
Bovine hemoglobin, Hb, Methemoglobin
Hemoglobin from bovine blood Hemoglobin
-diyl)]bis(2,2,2-trifluoroacetato-&kappa
HEMOGLOBIN SPRAY DRIED 98+% BY ELECTROPHORESIS
HEMOGLOBIN FROM BOVINE BLOOD, PGE. WITH 100 G*
HEMOGLOBIN FREEZE DRIED 98+% BY ELECTROPHORESIS
-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'
Monoclonal Anti-GSTM1 antibody produced in mouse
ydrochloride (1mg/mL in Methanol)|(6-APB Hydrochloride)
HEMOGLOBIN FROM BOVINE BLOOD, 2XCRYST., LYOPH., SALTFREE, P
Hemoglobin from bovine blood,Bovine hemoglobin, Hb, Methemoglobin
-(7-Hydroxy-3-oxo-3H-phenoxazine-4,6-diyl)]bis(2,2,2-trifluoroacetato-&kappa
Opiate Multi-component Mixture-5 (mixture of Codeine, Hydrocodone, Meperidine, (± | [EINECS(EC#)]
293-254-9 | [Molecular Formula]
NULL | [MDL Number]
MFCD00131282 | [MOL File]
9008-02-0.mol | [Molecular Weight]
226.231 |
| Chemical Properties | Back Directory | [Definition]
The respiratory protein of the red blood cells, it transfers oxygen from the lungs to the tissues and carbon dioxide from the tissues to the lungs. Its affinity for carbon monoxide is >200 times that for oxygen. Hemoglobin is a conjugated protein of molec | [storage temp. ]
2-8°C
| [solubility ]
0.6 M HCl: soluble20mg/mL | [form ]
substrate powder
| [color ]
Dark brown powder | [Water Solubility ]
Soluble in water. | [Uses]
Medicine, usually called hemoglobin. | [EPA Substance Registry System]
Hemoglobins(9008-02-0) |
| Hazard Information | Back Directory | [Description]
Haemoglobin, the oxygen-transport protein in the red blood cells, is a tetramer and each of the four chains
contains a haeme group. It is interesting to note that the four haeme groups in haemoglobin do not operate
independently. The release (and binding) of oxygen is a cooperative process, which means that the loss
(uptake) of the first oxygen molecule triggers the release of the remaining three.
The current model for oxygen binding in haemoglobin and myoglobin can be explained in the following
way. The deoxy form contains a high-spin Fe(II) centre, which, because of its size, does not form a plane with
its four nitrogen donor atoms. Instead, it is located slightly above the plane, drawn towards the His residue.
Once oxygen enters trans to the His residue, the iron centre is oxidised to a low-spin Fe3+ centre and O2 is
reduced to [O2]-. Both species contain an unpaired electron. The low-spin Fe3+ moves into the plane and
pulls the His residue down. This affects the remaining protein chain and triggers the uptake/release of oxygen
in the other three haeme groups. | [General Description]
Native hemoglobin from bovine erythrocytes. A major oxygen-transporting component of red blood cells that is also nitric oxide scavenger. Blocks carbachol-stimulated cGMP production. This preparation contains primarily Ferric-hemoglobin and must be reduced to the ferrous form to bind molecular oxygen. Note: this preparation contains primarily ferric-hemoglobin and must be reduced to the ferrous form to bind molecular oxygen. | [Biochem/physiol Actions]
The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues. | [Purification Methods]
Purify it from blood using CM-32 cellulose column chromatography. [Matsukawa et al. J Am Chem Soc 107 1108 1985.] For the purification of the and chains see Hill et al. Biochemical Preparations 10 55 1963. Histones (from S4A mouse lymphoma). The purification of histones uses a macroprocess column, heptafluorobutyric acid as solubilising and ion-pairing agent and an acetonitrile gradient. [McCroskey et al. Anal Biochem 163 427 1987.] |
|
|