ChemicalBook--->CAS DataBase List--->959551-10-1

959551-10-1

959551-10-1 Structure

959551-10-1 Structure
IdentificationBack Directory
[Name]

NIH-12848
[CAS]

959551-10-1
[Synonyms]

NIH-12848
NIH-12848, >98%
NIH12848;NIH 12848
NIH-12848, 959551-10-1
4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-
N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine
[Molecular Formula]

C20H14F3N3S
[MDL Number]

MFCD30738011
[MOL File]

959551-10-1.mol
[Molecular Weight]

385.41
Chemical PropertiesBack Directory
[Boiling point ]

441.6±45.0 °C(Predicted)
[density ]

1.384±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 25 mg/mL
[form ]

A crystalline solid
[pka]

5.05±0.30(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
Hazard InformationBack Directory
[Uses]

NIH-12848 is a a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, and also a potentially powerful tool for exploring the cell physiology of PI5P4Ks. Reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.
[storage]

Store at -20°C
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