1617-53-4
中文名称
穗花杉双黄酮
英文名称
Amentoflavone
CAS
1617-53-4
分子式
C30H18O10
MDL 编号
MFCD00017470
分子量
538.46
MOL 文件
1617-53-4.mol
更新日期
2024/05/27 15:49:28
1617-53-4 结构式
基本信息
中文别名
穗花杉双黄酮穗花双黄酮
英文别名
3',8''-BIAPIGENIN4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE
AMENTOFLAVONE
DIDEMETHYL-GINKGETIN
I3,II8 BIAPIGENIN
amenthoflavone
AMENTOFLACONE
AMENTOFLAVONE(SH)
AMENTOFLAVONE WITH HPLC
AMENTOFLAVONE hplc
2-(4-Hydroxyphenyl)-5,7-dihydroxy-8-[2-hydroxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
4',5,7-Trihydroxy-8-[2-hydroxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]flavone
5,7,4',5'',7'',4'''-Hexahydroxy-3',8''-biflavone
8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
所属类别
天然产物：黄酮类化合物物理化学性质
外观性状黄色结晶粉末，易溶于甲醇，几乎不溶于乙醚，来源于卷柏，杉木枝叶。
熔点>300°C (dec.)
沸点910.5±65.0 °C(Predicted)
密度1.656±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO（轻微）、甲醇（轻微、加热）、吡啶（轻微）
酸度系数(pKa)6.01±0.40(Predicted)
形态neat
颜色黄色
BRN380244
InChIKeyYUSWMAULDXZHPY-UHFFFAOYSA-N
LogP3.492 (est)
应用领域
用途1
一种具有抗病毒和抗炎作用的生物类黄酮。Amentoflavone is a bioflavonoid that has anti-viral and anti-inflammatory properties. The compound has been observed to inhibit the expression of INOS, LPS-induced activation of NFκB p50 (NF-κ B), translocation of p65 by LPS and block IKKα(I-κ B α) degradation in macrophages. Amentoflavone has been shown to up-regulate PPAR-γ and block the induction of COX-2. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site. The compound has demonstrated anti-viral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 μg/ml. Amentoflavone has also pronounced inhibition at an IC50 = 14.9 +/- 1.9 nM of benzodiazepine binding in vitro.用途2
穗花杉双黄酮具有抗肿瘤、清除自由基、舒张血管、降血糖的作用。