53-42-9
中文名称
3a-羟基-5b-雄甾烷-17-酮
英文名称
Etiocholanone
CAS
53-42-9
分子式
C19H30O
MDL 编号
MFCD00064133
分子量
274.44
MOL 文件
53-42-9.mol
更新日期
2024/04/26 14:05:45
53-42-9 结构式
基本信息
中文别名
还原胆烷醇酮还原尿睾酮
苯胆烷醇酮
3a-羟基-5b-雄甾烷-17-酮
英文别名
3ALPHA-ETIOCHOLANOLONE3ALPHA-HYDROXY-5BETA-ANDROSTAN-17-ONE
5BETA-ANDROSTAN-3ALPHA-OL-17-ONE
5BETA-ANDROSTAN-3A-OL-17-ONE
5BETA-ANDROSTERONE
ETIOCHOLAN-3ALPHA-OL-17-ONE
ETIOCHOLAN-3A-OL-17-ONE
ETIOCHOLANOLON
ETIOCHOLANOLONE
ETIOCHOLANONE
5beta-Androstan-17-one, 3alpha-hydroxy-
5-Isoandrosterone
Androstan-17-one, 3-hydroxy-, (3alpha,5beta)-
Androstan-3alpha-ol-17-one
Androsterone, (5beta)-
etiocholan-3A-ol-17-one crystalline
ETIOCHOLANOLONE (5B-ANDROSTAN-3A-OL-17-O NE)
5BETA-ANDROSTAN-3ALPHA-OL-17-ON 98%
ETIOCHOLANOLONE VETRANAL, 100 MG
etiocholan-3α-ol-17-one
物理化学性质
熔点148～150℃
沸点392.52°C (rough estimate)
密度0.9731 (rough estimate)
折射率1.5360 (estimate)
闪点2℃
储存条件room temp
溶解度DMSO: 100 mg/mL (344.31 mM)
酸度系数(pKa)15.14±0.60(Predicted)
形态固体
水溶解性20.33mg/L(25 ºC)
BRN2217625
常见问题列表
生物活性
Etiocholanolone (5β-Androsterone) 是睾酮的排泄代谢物，具有抗惊厥活性。相对于其对映体形式，Etiocholanolone 是一种较弱的神经甾醇类 GABAA receptor 正向变构调节剂。体外研究
Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect).
体内研究
Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice.