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3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
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- CAS号:
- 1026680-07-8
- 英文名:
- LB-100
- 英文别名:
- LB-100;CS-1762;LB-100, >95%;LB-100, 1026680-07-8;3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;3-(1-methylpiperazine-4-carbonyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid;methyl 2,5-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-3-carboxylate LB-100;LB-100 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
- 中文名:
- 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
- 中文别名:
- 3-(4-甲基哌嗪-1-羰基)-7-氧杂双环[2.2.1]庚烷-2-甲酸;3-(4-甲基哌嗪-1-羰基)-7-氧杂双环[2.2.1]庚烷-2-羧酸
- CBNumber:
- CB12725546
- 分子式:
- C13H20N2O4
- 分子量:
- 268.3089
- MOL File:
- 1026680-07-8.mol
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3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID化学性质
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熔点:
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>214°C (dec.)
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储存条件:
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Amber Vial, -20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated)
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形态:
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Solid
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颜色:
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White
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3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID性质、用途与生产工艺
LB-100是水溶性的protein phosphatase 2A (PP2A)抑制剂,在BxPc-3和Panc-1细胞中,IC50分别为0.85 μM和3.87 μM。
LB-100 可有效抑制BxPc-3和Panc-1细胞的生长,IC50值分别为2.3 μM和1.7 μM。BxPc-3、Panc-1和SW1990细胞经LB-100处理后,PP2A活性下降30-50%。LB-100提高细胞内的阿霉素浓度(约为对照组的2.5倍),并使肿瘤细胞对阿霉素的细胞毒性更加敏感。LB-100增加VEGF分泌,从而提高HIF-1α-VEGF介导的血管生成。
在小鼠胰腺癌异种移植模型中,LB-100 (2毫克/千克,腹腔注射)提高了化疗药物阿霉素的疗效。LB-100提高了肿瘤微血管密度和肿瘤表面的血流速度。
3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | XW163203253101 | 试剂LB-100 LB-100? | | 25mg | 3290元 |
2024/01/16 | S7537 | 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID LB-100 | 1026680-07-8 | 5mg | 1198.13元 |
3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
生产厂家
1026680-07-8, 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID 相关搜索:
- Inhibitors
- 药靶配体
- 化工原料
- 小分子抑制剂,天然产物
- 抑制剂
- 小分子抑制剂
- 3-(4-甲基哌嗪-1-羰基)-7-氧杂双环[2.2.1]庚烷-2-甲酸
- 3-(4-甲基哌嗪-1-羰基)-7-氧杂双环[2.2.1]庚烷-2-羧酸
- 1026680-07-8
- CS-1762
- LB-100, >95%
- LB-100, 1026680-07-8
- methyl 2,5-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-3-carboxylate LB-100
- LB-100 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
- 3-(1-methylpiperazine-4-carbonyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid
- LB-100
- 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID