法倔唑
|
|
|
- CAS号:
- 102676-47-1
- 英文名:
- FADROZOLE
- 英文别名:
- Afema;FAD286;CS-2710;FAD 286);CGS-16949;FADROZOLE;CGS-169494;FADROZOLE USP/EP/BP;Fadrozole
(CGS 16949A;Fadrozole Hydrochloride Hydrate
- 中文名:
- 法倔唑
- 中文别名:
- 法倔唑;法曲唑(CGS16949A);AROMATASE抑制剂(FADROZOLE);4-(5,6,7,8-四氢咪唑[1,5-A]吡啶-5-基)苯腈;4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯腈;4-(5,6,7,8-四氢咪唑并[1,5-Α]吡啶-5-基)苯腈;4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯甲腈
- CBNumber:
- CB3271421
- 分子式:
- C14H13N3
- 分子量:
- 223.27
- MOL File:
- 102676-47-1.mol
|
|
|
法倔唑性质、用途与生产工艺
Fadrozole (CGS16949A)是一种有效的、选择性aromatase抑制剂，IC50为4.5 nM, 对aromatase比对其他细胞色素P450酶更有选择性。
| Target | Value |
Aromatase
()
|
4.5 nM
|
Fadrozole hydrochloride is a very potent inhibitor of both human placental and rat ovarian aromatase. In hamster ovarian slices, fadrozole hydrochloride inhibits the production of estrogen with an IC
50
of 0.03 μM. The production of progesterone is inhibited with an IC
50
of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of fadrozole hydrochloride. .
Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED
50
of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED
50
of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars dta mas in female rats, and reduces the of spontaneous hcu ar tumours in male and female rats. Administration of fadrozole in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole treatment returns these levels to baseline values.
化学性质
熔点117～118℃。
盐酸法屈唑(Fadrozole Hydrochloride)：C14H13N3?HCl。[102676-96-0]。从异丙醇结晶，熔点231--233℃。溶于水。
用途
芳香酶抑制剂。用于治疗乳腺癌。
生产方法
由相应的羧酸化物在二氯乙烷中，浓硫酸存在下，通入氨气进行氨解得到。
法倔唑
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-14247A | 法倔唑
Fadrozole | 102676-47-1 | 5mg | 660元 |
| 2024/04/30 | HY-14247A | 法倔唑
Fadrozole | 102676-47-1 | 10mM * 1mLin DMSO | 726元 |
法倔唑
生产厂家
全球有 76家供应商
法倔唑国内生产厂家
102676-47-1, 法倔唑 相关搜索:
- FDA批准的配体
- 细胞生物学试剂
- 药物
- 其它抗肿瘤药物
- 抗肿瘤药
- 法曲唑(CGS16949A)
- 4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯腈
- 4-(5,6,7,8-四氢咪唑[1,5-A]吡啶-5-基)苯腈
- 4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯甲腈
- AROMATASE抑制剂(FADROZOLE)
- 4-(5,6,7,8-四氢咪唑并[1,5-Α]吡啶-5-基)苯腈
- 法倔唑
- 102676-47-1
- (Rac)-FAD286,inhibit,Fadrozole,CGS 16949A,Inhibitor,Aromatase
- FAD 286)
- FADROZOLE USP/EP/BP
- CS-2710
- Fadrozole
(CGS 16949A
- FAD286
- 4-{5H,6H,7H,8H-iMidazo[1,5-a]pyridin-5-yl}benzonitrile
- Benzonitrile,4-(5,6,7,8-tetrahydroiMidazo[1,5-a]pyridin-5-yl)-
- 4-(5，6，7，8-Tetrahydroimidazo[1，5-α]pyridin-5-y1)benzonitrile
- CGS-169494
- Afema
- Fadrozole Hydrochloride Hydrate
- CGS-16949
- 5,6,7,8-Tetrahydro-5-(4-cyanophenyl)imidazo[1,5-a]pyridine
- 4-[[5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin]-5-yl]benzonitrile
- 4-[(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin)-5-yl]benzonitrile
- 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine-5-yl)benzonitrile
- FADROZOLE