硝酸毛果芸香碱
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- CAS号:
- 148-72-1
- 英文名:
- Pilocarpine nitrate
- 英文别名:
- Nitrat;Pilocarpine nitrate for system suitability CRS;Pilagan;pilofrin;Pilocarpinnitrat;Einecs 205-723-7;Pilocarpin Nitrate;Pilocarpini nitras;PILOCARPINE NITRATE;p.v.carpineliquifilm
- 中文名:
- 硝酸毛果芸香碱
- 中文别名:
- 硝酸匹鲁卡品;匹鲁卡品硝酸盐;硝酸毛果芸香碱;硝酸异毛果芸香碱;毛果芸香碱硝酸盐;毛果芸香碱 硝酸酯;硝酸毛果芸香碱杂质C;硝酸匹鲁卡品 EP标准品;硝酸毛果芸香碱 USP标准品;硝酸匹鲁卡品(硝酸毛果芸香碱)
- CBNumber:
- CB4237796
- 分子式:
- C11H17N3O5
- 分子量:
- 271.27
- MOL File:
- 148-72-1.mol
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硝酸毛果芸香碱化学性质
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熔点:
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173,5-174°C
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比旋光度:
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D +77 to +83° (c = 10)
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折射率:
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81 ° (C=2, H2O)
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储存条件:
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2-8°C
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溶解度:
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H2O: 0.1 g/mL, clear, very faintly yellow
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形态:
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powder
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颜色:
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white
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旋光性 (optical activity):
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[α]25/D +83°, c = 10 in H2O(lit.)
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Merck:
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14,7424
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BRN:
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4171406
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CAS 数据库:
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148-72-1(CAS DataBase Reference)
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EPA化学物质信息:
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Pilocarpine nitrate (148-72-1)
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硝酸毛果芸香碱性质、用途与生产工艺
硝酸毛果芸香碱呈无色结晶或白色结晶性粉末；无臭；遇光易变质。其可用于青光眼、虹膜炎的治疗。
1．对本药过敏者。
2．支气管哮喘患者。
3．急性虹膜炎、虹膜睫状体炎等不应缩瞳的眼病患者。
Pilocarpine nitrate 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。
To evaluate the cytotoxicity of Pilocarpine, the morphology and viability of human corneal stromal (HCS) cells are examined by light microscopy and MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- and time-dependent proliferation retardation and morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, and eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L and controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time and concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show no significant difference to controls. The partial muscarinic agonist, Pilocarpine, evokes concentration-dependent relaxation with an EC
50
of 2.4 mM in isolated segments of rat tail artery that were constricted with Penylephrine (10 to 200 nM).
The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na
+
concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).
生产方法
可由植物毛果芸香提取毛果芸香碱后，再用硝酸处理而制得。
硝酸毛果芸香碱
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B1006 | Pilocarpine nitrate | | 50 mg | 300元 |
| 2024/04/30 | HY-B1006 | Pilocarpine nitrate | | 100 mg | 500元 |
硝酸毛果芸香碱
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全球有 131家供应商
硝酸毛果芸香碱国内生产厂家
148-72-1, 硝酸毛果芸香碱 相关搜索:
- API
- Biochemistry
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- Alkaloids
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- Cholinergics
- Chemical Structure
- AgonistsDrugs of Abuse
- Inhibitors
- 药靶配体
- 杂质对照品
- 原料
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 中药对照品
- 对照品
- 标准品
- Alkaloids
- Alkaloids (Others)
- C11H16N2O2HNO3
- 硝酸毛果芸香碱杂质C
- 硝酸毛果芸香碱 USP标准品
- 硝酸匹鲁卡品系统适应性 EP标准品
- 硝酸匹鲁卡品 EP标准品
- 匹鲁卡品硝酸盐
- 硝酸毛果芸香碱杂质Ⅰ( 硝酸异毛果芸香碱)(3R,4R)-3-乙基-4-[(1-甲基-1H-咪唑-5-基)甲基]二氢呋喃-2(3H)-酮,硝酸盐
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- 毛果芸香碱 硝酸酯
- 硝酸毛果芸香碱
- 硝酸匹鲁卡品
- 毛果芸香碱硝酸盐
- 硝酸匹鲁卡品(硝酸毛果芸香碱)
- 硝酸异毛果芸香碱
- (3S,4R)-3-乙基二氢-4-[(1-甲基-1H-咪唑-5-基)甲基]-2(3H)-呋喃酮硝酸盐
- 148-72-1
- Ametryn Impurity 21(Simetryne)
- (2R,3R)-2-ethyl-3-(hydroxymethyl)-4-(1-methyl-1H-imidazol-5-yl)butanoic acid (isopilocarpic acid)
- Pilocarpine,Inhibitor,inhibit,mAChR,Muscarinic acetylcholine receptor,Pilocarpine nitrate
- Pilocarpinenitratesal
- Nitrat
- Pilocarpine nitrate for system suitability CRS
- Pilocarpine Nitrate Impurity Ⅰ:(3R,4R)-3-ethyl-4-((1-Methyl-1H-iMidazol-5-yl)Methyl)dihydrofuran-2(3H)-one nitrate
- Pilocarpine nitrate CRS
- Pilocarpine nitrate USP/EP/BP
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Pilocarpine Nitrate Q: What is the CAS Number of
Pilocarpine Nitrate Q: What is the storage condition of
Pilocarpine Nitrate Q: What are the applications of
Pilocarpine Nitrate
- Pilocarpine Nitrate Impurity Ⅰ:(3R,4R)-3-ethyl-4-((1-Methyl-1H-iMidazol-5-yl)Methyl)dihydrofuran-2(3H)-one nitrate
- Pilocarpine Nitrate (1539009)
- pilofrin
- pilocarpinesubnitrate
- Pilocarpinenitrateusp
- pilocarpine,mononitrate
- p.v.carpineliquifilm
- 3-ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanon(3s-cis)
- PILOCARPINE NITRATE SALT
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