7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
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- CAS号:
- 496864-16-5
- 英文名:
- RP107
- 英文别名:
- RP107;ALOISINE A;ALOISINE A RP107;Aloisine A - CAS 496864-16-5 - Calbiochem;4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-;7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE;7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
- 中文名:
- 7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
- 中文别名:
- 化合物 T21377;4-(7-丁基-5H-吡咯并[2,3-B]吡嗪-6-基)苯酚;7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
- CBNumber:
- CB4265483
- 分子式:
- C16H17N3O
- 分子量:
- 267.33
- MOL File:
- 496864-16-5.mol
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7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪化学性质
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熔点:
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281-283°C
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密度:
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1.227
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Yellow solid
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酸度系数(pKa):
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9.67±0.15(Predicted)
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颜色:
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Light Orangish Yellow
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7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪性质、用途与生产工艺
用途
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk
1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3β, respectively), and
c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).
7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
上下游产品信息
上游原料
下游产品
7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
生产厂家
496864-16-5, 7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 相关搜索:
- Heterocycles
- Aromatics
- Protein Kinase Inhibitors and Activators
- Inhibitors
- All Inhibitors
- 化合物 T21377
- 4-(7-丁基-5H-吡咯并[2,3-B]吡嗪-6-基)苯酚
- 7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
- 496864-16-5
- 4-(7-butyl-l,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-l-one
- 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-1-one
- Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-
- Aloisine A - CAS 496864-16-5 - Calbiochem
- 7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
- 4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
- RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine
- RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine
- 7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
- 7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE
- ALOISINE A RP107
- ALOISINE A
- 4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL
- RP107