甘草西定
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- CAS号:
- 30508-27-1
- 英文名:
- licoricidin
- 英文别名:
- licoricidin;Licorisoflavan B;LICORICIDIN (LCD);7-O-Demethyllicorisoflavan A;1,3-Benzenediol,4-[(3R)-3,4-dihydro-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]-2-(3-methyl-2-buten-1-yl)-
- 中文名:
- 甘草西定
- 中文别名:
- 甘草西定;ⅡA-8 (甘草西定)
- CBNumber:
- CB51380788
- 分子式:
- C26H32O5
- 分子量:
- 424.53
- MOL File:
- 30508-27-1.mol
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甘草西定化学性质
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熔点:
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161.0-162.5℃
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沸点:
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610.8±55.0 °C(Predicted)
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密度:
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1.171±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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10.10±0.40(Predicted)
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甘草西定性质、用途与生产工艺
Licoricidin (LCD) 从甘草 Glycyrrhiza uralensis Fisch 中分离，具有抗癌活性。Licoricidin (LCD) 通过诱导周期停滞，诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，可用于结直肠癌的研究。Licoricidin (LCD) 通过抑制肿瘤血管生成和淋巴管生成以及肿瘤组织局部微环境的变化抑制肺转移。Licoricidin (LCD) 通过体外和体内 Akt 和 NF-κB 途径的失活，增强吉西他滨诱导的骨肉瘤 (OS) 细胞的细胞毒性。Licoricidin (LCD) 通过 ROS 清除阻断 UVA 诱导的光老化，限制 MMP-1 的活性，被认为是新的局部应用的抗衰老制剂中的活性成分。
Licoricidin (LCD) (0-20 μM; 24 hours) dose-dependently inhibits the viability of colon cancer cell lines with various pathological and genetic characters, namely SW480, HCT116, SW620 and LoVo cells, with IC
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values of 7.2, 5.4, 4.5 and 5.1 μM, respectively.
Licoricidin (LCD) (0-20 μM; 0-12 hours) induces cell apoptosis was accompanied with the activation of caspase-3 by cleavage in a time- and dose-dependent manner.
Licoricidin (LCD) (0-20 μM; 0-12 hours) induces autophagy of SW480 cells, increases the cleavage of LC3-I to LC3-II and the degradation of p62 in a time and dose dependent manner.
Licoricidin (LCD) (0-5 μg/ml; 18 hours) inhibits cell migration, MMP-9 secretion, and VCAM expression in 4T1 cells.
Cell Viability Assay
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Cell Line:
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SW480, HCT116, SW620 and LoVo cells
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Concentration:
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0-20 μM
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Incubation Time:
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24 hours
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Result:
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Decreased colon cancer cell lines viability.
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Western Blot Analysis
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Cell Line:
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SW480 cells
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Concentration:
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0 μM, 2.5 μM, 5 μM, 10 μM, 20 μM
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Incubation Time:
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0 hours, 1 hour, 3 hours, 6 hours, 12 hours
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Result:
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Induced cell apoptosis.
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Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 15 days) significantly inhibited the growth of SW480 xenografts in nude mice with an inhibitory rate of 43.5%.
Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days) reduces pulmonary metastasis and the expression of CD45, CD31, HIF-1α, iNOS, COX-2, and VEGF-A in tumor tissues, additionally, decreases protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 in tumor tissues of licoricidin-treated mice.
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Animal Model:
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SW480 xenografted tumor growth in nude mice
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Dosage:
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5, 10, or 20 mg/kg
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Administration:
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Intraperitoneal injection; once daily; 15 days
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Result:
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Decreased tumor volumes.
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Animal Model:
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BALB/c mouse orthotopic model
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Dosage:
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5, 10, or 20 mg/kg
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Administration:
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Intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days
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Result:
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Inhibited Lung Metastasis of 4T1 Murine Mammary Carcinoma cells.
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甘草西定
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-N3387 | 甘草西定
Licoricidin | 30508-27-1 | 1 mg | 2980元 |
30508-27-1, 甘草西定 相关搜索:
- 抑制剂
- 黄酮
- 标准品
- 中药对照品
- ⅡA-8 (甘草西定)
- 甘草西定
- 30508-27-1
- LICORICIDIN (LCD)
- 1,3-Benzenediol,4-[(3R)-3,4-dihydro-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]-2-(3-methyl-2-buten-1-yl)-
- Licorisoflavan B
- 7-O-Demethyllicorisoflavan A
- licoricidin