对称N,N-二甲基精氨酸
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- CAS号:
- 30344-00-4
- 英文名:
- N,N'-Dimethylarginine
- 英文别名:
- SDMA-d6;H-Arg(Me, Me)-OH (sym);NG'-Dimethyl-L-arginine;Symmetric dimethylarginine;Nω,N'ω-dimethyl-L-arginine;NG,NG’-Dimethy-L-arginine-d6;L-Arg(Me, Me)-OH (syMMetrical);L-Arg(Me, Me)-OH (asyMMetrical);N,N'-Dimethylarginine USP/EP/BP;L-Arg(Me,Me)-OH(symmetrical), >97%
- 中文名:
- 对称N,N-二甲基精氨酸
- 中文别名:
- 对称性二甲基精氨酸;N,N-二甲基精氨酸;对称N,N-二甲基精氨酸;N,N-二甲基精氨酸(精氨酸杂质23);对称N,N'-二甲基精氨酸溶液,100PPM;(S)-2-氨基-5-((双(甲基氨基)亚甲基)氨基)戊酸;(2S)-2-氨基-5-[(N,N'-二甲基甲脒基)氨基]戊酸;NG,NG′-二甲基-L-精氨酸二(对羟基偶氮苯-P'-磺酸盐)盐
- CBNumber:
- CB91236269
- 分子式:
- C8H18N4O2
- 分子量:
- 202.25
- MOL File:
- 30344-00-4.mol
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对称N,N-二甲基精氨酸化学性质
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沸点:
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353.5±52.0 °C(Predicted)
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密度:
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1.22±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Room temperature
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溶解度:
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DMSO : 50 mg/mL (247.22 mM; ultrasonic and adjust pH to 3 with 1M HCl)
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酸度系数(pKa):
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2.48±0.24(Predicted)
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形态:
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Orange powder.
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稳定性:
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Very Hygroscopic
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对称N,N-二甲基精氨酸性质、用途与生产工艺
SMDA (symmetric dimethylarginine)是精氨酸的甲基化形式，存在于所有的有核细胞中，在蛋白质水解后被释放到循环体统中，通过肾脏排泄，在人、犬类和猫中与肾小球滤过率相关。
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Human Endogenous Metabolite
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SDMA is the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate. SDMA inhibits dose dependently the NO synthesis in intact endothelial cells, whereas it has no effect on protein expression of NOS. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α.
SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR. Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction.
对称N,N-二甲基精氨酸
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | S5838 | SDMA | 30344-00-4 | 10mM (1mL in DMSO) | 1040.13元 |
| 2024/04/30 | S5838 | 对称N,N-二甲基精氨酸
SDMA | 30344-00-4 | 25mg | 2212.11元 |
30344-00-4, 对称N,N-二甲基精氨酸 相关搜索:
- Pharmaceuticals
- Isotope Labeled Compounds
- Intermediates & Fine Chemicals
- Amino Acids & Derivatives
- Isotope Labelled Compounds
- 代谢物
- 杂质
- 氨基酸
- 非天然氨基酸
- C8H12D6N4O2
- 30135-93-6
- N,N-二甲基精氨酸(精氨酸杂质23)
- (2S)-2-氨基-5-[(N,N'-二甲基甲脒基)氨基]戊酸
- N,N-二甲基精氨酸
- (S)-2-氨基-5-((双(甲基氨基)亚甲基)氨基)戊酸
- 对称性二甲基精氨酸
- NG,NG′-二甲基-L-精氨酸二(对羟基偶氮苯-P'-磺酸盐)盐
- 对称N,N-二甲基精氨酸
- 对称N,N'-二甲基精氨酸溶液,100PPM
- 30344-00-4
- (2S)-2-amino-5-[(N,N-dimethylcarbamimidoyl)amino]pentanoic
- inhibit,Inhibitor,Endogenous Metabolite,SDMA
- H-Arg(Me, Me)-OH (sym)
- N,N'-Dimethylarginine USP/EP/BP
- L-Ornithine,N5-[(methylamino)(methylimino)methyl]-
- L-Arg(Me,Me)-OH(symmetrical), >97%
- Nω,N'ω-dimethyl-L-arginine
- NG'-Dimethyl-L-arginine
- NG,NG'-Dimethy-L-arginine Solution, 100ppm
- (S)-2-Amino-5-((bis(methylamino)methylene)amino)pentanoic acid
- SDMA-d6
- NG,NG’-Dimethy-L-arginine-d6
- N5-[Bis(methylamino)methylene]-L-ornithine-d6
- N5-[(Dimethylamino)iminomethyl]-L-ornithine-d6
- Symmetric dimethylarginine
- L-Arg(Me, Me)-OH (asyMMetrical)
- L-Arg(Me, Me)-OH (syMMetrical)
- (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid