Isoliquiritigenin通过抑制大鼠晶状体醛糖还原酶可能能够有效预防糖尿病并发症,IC50为320 nM,并且能够预防山梨糖醇在人类红细胞中的积累,IC50为2.0 μM。 Isoliquiritigenin通过抑制单酚酪氨酸酶和二酚酪氨酸酶的活性可以用作美白剂,IC50为8.1 μM。 在DU145和LNCaP 细胞系中,Isoliquiritigenin诱导细胞周期停滞并抑制细胞生长。在人类胃癌MGC-803细胞中, Isoliquiritigenin通过增加细胞内游离钙离子浓度,并降低线粒体膜电位(Deltapsi(m))而诱导细胞凋亡。
Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steato sis-induced oxidative stress. ISL induces quinone reductase-1, a phase II enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in murine hepatoma cells.