Dothiepin
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- CAS-Nr.
- 113-53-1
- Englisch Name:
- Dothiepin
- Synonyma:
- iz914;Dothep;IZ 914;dosulepin;Methiaden;DOTHIEPIN;Dosulepine;Prothiaden;Prothiadene;Dolsulepine
- CBNumber:
- CB0378413
- Summenformel:
- C19H21NS
- Molgewicht:
- 295.44
- MOL-Datei:
- 113-53-1.mol
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Dothiepin Eigenschaften
- Schmelzpunkt:
- 55-57°
- Siedepunkt:
- bp0.05 171-172°
- Dichte
- 1.1022 (rough estimate)
- Brechungsindex
- 1.5300 (estimate)
- storage temp.
- Refrigerator
- Löslichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Thick Oil to Low-Melting Solid
- pka
- 9.35±0.28(Predicted)
- Farbe
- Off-White to Light Yellow
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H362 |
Kann Säuglinge über die Muttermilch schädigen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
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P201, P260, P263, P264, P270,P308+P313 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt während der Schwangerschaft /und der Stillzeit vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Dothiepin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Pale Yellow Low Melting Solid
History
Described in the 1960s by the Czech company Sdruzeni Podniku pro Zdravotnickon Vyrobu; SPOFA (Spofa, 1962)
Verwenden
A tricyclic antidepressant.
Clinical Use
Dosulepin (also referred to as dothiepin) is a member of the TCA family and has similar clinical uses as amitrip- tyline, thus providing effective treatment of depression (Goldstein and Claghorn, 1980; Lancaster and Gonzales, 1989; Donovan et al., 1991) and also against pain (Feinmann et al., 1984; Caruso et al., 1987) and tinnitus. Like amitriptyline it has sedative properties, however its anti-muscarinic side-effects are less pronounced. Dosulepin is readily absorbed from the GI tract and extensively demethylated while undergoing a first-pass effect. Metabolic pathways include next to hydroxylation and N-oxidation steps, S-oxidation. Elimination half-lifes vary from 14 to 24 hours interindividually (Maguire et al., 1982; Yu et al., 1986; Ilett et al., 1993).
Dothiepin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dothiepin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 43)Lieferanten
113-53-1()Verwandte Suche:
- (3E)-3-Dibenzo[b,E]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine
- 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin
- 1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-
- 3-Dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-1-propamine
- 3-dibenzo(b,e)thiepin-11(6h)-ylidene-n,n-dimethyl-1-propanamin
- 3-Dibenzo[b,e]thiepin-11(6H)-ylidine-N,N-dimethyl-propanamine
- Dibenzo[b,e]thiepin, 1-propanamine deriv.
- Dibenzo[b,e]thiepin-delta11(6H),gamma-propylamine, N,N-dimethyl-
- dosulepin
- Dosulepine
- Dothep
- IZ 914
- iz914
- n,n-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6h),gamma))-propylamin
- N,N-Dimethyldibenzo(b,e)thiepin-delta-sup(11(6H),gamma)propylamine
- Propylamine, N,N-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6H),gamma))-
- Prothiaden
- Prothiaden spofa
- Prothiadene
- 3-DIBENZO[B,E] THIEPIN-11-(6H)-YLIDENE-N,N-DIMETHYL-PROPONAMINE
- (E)-3-[Dibenzo[b,e]thiepin-11(6H)-ylidene]-N,N-dimethyl-1-propanamine
- (E)-3-[Dibenzo[b,e]thiepin-11(6H)-ylidene]-N,N-dimethylpropane-1-amine
- Dothiepin (cis/trans)
- 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-diMethyl-
- DOTHIEPIN,3-DIBENZO[B,E] THIEPIN-11-(6H)-YLIDENE-N,N-DIMETHYL-PROPONAMINE
- Dolsulepine
- Methiaden
- CIS,TRANS-DOTHIEPIN,1.0MG/MLINMETHANOL
- 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine
- N,N-Dimethyl- dibenzo[b,e]thiepin-11(6H),-propylamine
- DOTHIEPIN
- 3-(6,11-dihydrodibenzo(b,e)thiepin-11-ylidene)propyldimethylamine
- Dothiepin-d3 Maleate
- 113-53-1
- Chemical Amines
- Amines
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
