(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron

Taxifolin Struktur
480-18-2
CAS-Nr.
480-18-2
Bezeichnung:
(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron
Englisch Name:
Taxifolin
Synonyma:
DIHYDROQUERCETIN;distylin;taxifoliol;Larch extract;(+)-TAXIFOLIN;(2R,3R)-(+)-Taxifolin;(2R,3R)-DIHYDROQUERCETIN;Taxifolin (Dihydroquercetin);CPD-474;Lavitol
CBNumber:
CB0402424
Summenformel:
C15H12O7
Molgewicht:
304.25
MOL-Datei:
480-18-2.mol

(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Eigenschaften

Schmelzpunkt:
230-233°C (dec.)
Siedepunkt:
365.09°C (rough estimate)
Dichte
1.3326 (rough estimate)
Brechungsindex
1.4790 (estimate)
storage temp. 
-20°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
pka
7.39±0.60(Predicted)
Aggregatzustand
Solid
Farbe
White to Yellow
BRN 
5299277
InChI
InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
InChIKey
CXQWRCVTCMQVQX-LSDHHAIUSA-N
SMILES
[C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
LogP
0.950
CAS Datenbank
480-18-2(CAS DataBase Reference)
EPA chemische Informationen
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- (480-18-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 22
S-Sätze: 22-24/25
WGK Germany  3
RTECS-Nr. LK6920000
HazardClass  IRRITANT
HS Code  29329990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Taxifolin, a chemical substance extracted from pine plants such as larch and Douglas fir. It belongs to the bioflavonoid pseudo-vitamin P, and its scientific name is dihydroquercetin. Japanese scholar Fukui first isolated it from the leaves of conifers (Chamaecyparis obtusa), and its biological activity was subsequently discovered and confirmed.

Chemische Eigenschaften

Yellow Solid

Verwenden

An antioxidant flavenoid.

Definition

ChEBI: A taxifolin that has (2R,3R)-configuration.

Application

Taxifolin is a flavonoid commonly found in onion, milk, French maritime pine bark and Douglas fir bark. It is also used in various commercial preparations like Legalon?, Pycnogenol?, and Venoruton?. This review focuses on taxifolin’s biological activities and related molecular mechanisms. It showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders. The anti-cancer activity was more prominent than other activities evaluated using different in vitro and in vivo models. Further research on the pharmacokinetics, in-depth molecular mechanisms, and safety profile using well-designed randomized clinical studies are suggested to develop a drug for human use.

Allgemeine Beschreibung

Taxifolin is a plant flavonoid, which may find applications in the treatment of coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction and sequelae.

(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 442)Lieferanten
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Wuhan Haorong Biotechnology Co.,ltd
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CHINA 139 55
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zheyansh@163.com CHINA 3619 58

480-18-2((2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron)Verwandte Suche:


  • 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on
  • 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on(
  • 2,3-dihydro-3,3’,4’,5,7-pentahydroxy-flavon
  • 2theta-trans)-
  • 3,3’,4’,5,7-pentahydroxy-flavanon
  • dihydro-querceti
  • TAXIFOLIN(P)
  • TAXIFOLIN, (+)-(RG)
  • (2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone
  • Dihydroquercetin,~99%
  • TAXIFOLIN SNAP-N-SHOOT 0.1mg/mL(P)
  • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
  • (+)-Taxifolin ,98%
  • (+)-trans Taxifolin
  • 2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-
  • 2-(3,4,5-Trihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4H-1-benzopyran-4-one
  • (3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
  • 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro
  • taxifolin or dihydroquercetin
  • CPD-474
  • trans dihydroquercetin
  • (2R,3R)-3,3′,4′,5,7-Pentahydroxyflavanone (2R,3R)-Dihydroquercetin
  • (2R,3R)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-1-benzopyran-4-one
  • Diquertin
  • Lariksin
  • Lavitol
  • (+)-3,3',4',5,7-PENTAHYDROXYFLAVANONE
  • 3,3',4',5,7-PENTAHYDROXYFLAVANONE
  • (2R,3R)-3,3',4',5,7-PENTAHYDROXYFLAVANONE
  • 3,5,7,3',4'-PENTAHYDROXYFLAVANONE
  • (+)-DIHYDROQUERCETIN
  • TAXIFOLIN
  • TAXIFOLIN, (+)-
  • Taxifoliol,Distylin
  • 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroMan-4-one
  • Taxifolin SynonyMs (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone
  • 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
  • (2S,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
  • 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-chromanone
  • 3,3',4',5,7-Pentahydroxydihydroflavone
  • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-trans)-
  • FLAVANONE, 3,3',4',5',7-PENTAHYDROXY
  • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-5-olate
  • Taxifolin,TAX
  • Taxifolin USP/EP/BP
  • (+)-(2R,3R)-Dihydroquercetin
  • (+)-Dihydroquercetin
  • Dihydroquercetin/Taxifolin
  • (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
  • distylin
  • (2R,3R)-(+)-Taxifolin
  • DIHYDROQUERCETIN
  • Taxifolin (Dihydroquercetin)
  • Larch extract
  • (2R,3R)-DIHYDROQUERCETIN
  • (+)-TAXIFOLIN
  • taxifoliol
  • (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
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