Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-
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- CAS-Nr.
- 13553-79-2
- Bezeichnung:
- Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-
- Englisch Name:
- Rifamycin S
- Synonyma:
- rifamycin;100722;rifomycins;nci144-130;RIFAMYCIN S;RIFAMPICIN S;Rifamycin S CRS;Rifamycin S USP/EP/BP;Rifaximin EP Impurity E;Rifamycin EP Impurity B
- CBNumber:
- CB1187968
- Summenformel:
- C37H45NO12
- Molgewicht:
- 695.75
- MOL-Datei:
- 13553-79-2.mol
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Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo- Eigenschaften
- Schmelzpunkt:
- 179-181°C (dec.)
- alpha
- D20 +476° (c = 0.1 in methanol)
- Siedepunkt:
- 700.89°C (rough estimate)
- Dichte
- 1.2387 (rough estimate)
- Brechungsindex
- 1.6630 (estimate)
- storage temp.
- -20°C Freezer
- Löslichkeit
- Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly)
- pka
- 3.85±0.70(Predicted)
- Farbe
- Orange to Dark Orange
- maximale Wellenlänge (λmax)
- 390nm(MeOH)(lit.)
- Merck
- 14,8217
- InChIKey
- BTVYFIMKUHNOBZ-ODRIEIDWSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| RTECS-Nr. |
KD1925000 |
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| HS Code |
2941.90.1050 |
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| Toxizität |
LD50 in mice (mg/kg): 122 i.v.; 258 i.p.; 3000 orally (Sensi, 1964) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H371 |
Kann die Organe schädigen. |
Spezifische Zielorgan-Toxizität |
Kategorie 2 |
Warnung |
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P260, P264, P270, P309+P311, P405,P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P405 |
Unter Verschluss aufbewahren. |
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Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo- Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Rifamycin S (Rifaximin EP Impurity E) is a semi-synthetic antibiotic.
Clinical Use
The rifamycins are a group of chemically related antibioticsobtained by fermentation from cultures of Streptomycesmediterranei. They belong to a class of antibiotics called theansamycins that contain a macrocyclic ring bridged acrosstwo nonadjacent positions of an aromatic nucleus. The termansa means “handle,” describing well the topography of thestructure. The rifamycins and many of their semisynthetic derivativeshave a broad spectrum of antimicrobial activity.They are most notably active against Gram-positive bacteriaand M. tuberculosis. However, they are also active againstsome Gram-negative bacteria and many viruses. Rifampin, asemisynthetic derivative of rifamycin B, was released as anantitubercular agent in the United States in 1971. A secondsemisynthetic derivative, rifabutin, was approved in 1992 forthe treatment of atypical mycobacterial infections.
The chemistry of rifamycins and other ansamycins hasbeen reviewed. All of the rifamycins (A, B, C, D, and E) arebiologically active. Some of the semisynthetic derivatives ofrifamycin B are the most potent known inhibitors of DNAdirectedRNA polymerase in bacteria, and their action isbactericidal. They have no activity against the mammalianenzyme. The mechanism of action of rifamycins as inhibitorsof viral replication appears to differ from that for their bactericidalaction. Their net effect is to inhibit the formation of thevirus particle, apparently by preventing a specific polypeptideconversion.77 Rifamycins bind to the β subunit of bacterialDNA-dependent RNA polymerases to prevent chain initiation.78 Bacterial resistance to rifampin has been associatedwith mutations leading to amino acid substitution in the subunit.78 A high level of cross-resistance between variousrifamycins has been observed.
Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 226)Lieferanten
13553-79-2(Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-)Verwandte Suche:
Rifamycin
Rifamycin, 4-O-(Carboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-, γ-Lacton
Rifamycin, Natriumsalz
Rifamycin, 4-O-(Carboxymethyl)-
Rifamycin, 3-Formyl-
Rifapentin
Rifampicin
Riboflavin
2,5-Dimethyl-p-anisaldehyd
Rifamycin, 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-
- 1,4-dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
- 2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,6,9,11(2h)-tetron
- 4-dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
- RIFAMPICIN S
- RIFAMYCIN S
- 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-aceta
- nci144-130
- rifomycins
- 5,17,19,21-Tetrahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-2,7-(epoxypentadeca[1,11,13]trieniMino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone 21-Acetate
- Rifamycin, 1,4-dideoxy-1,4-dihydro-1,4-dioxo-
- Rifaximin EP Impurity E
- Rifaximin EP Impurity E (Rifamycin S)
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate (7CI,8CI)
- Rifamycin EP Impurity B
- Rifaximin impurity E (EP)
- Rifaximin Impurity 5 (Rifaximin EP Impurity E)
- Rifamycin S CRS
- Rifamycin Impurity 2(Rifamycin EP Impurity B)（Rifamycin S)
- Rifamycin S USP/EP/BP
- Rifamycin SQ: What is
Rifamycin S Q: What is the CAS Number of
Rifamycin S Q: What is the storage condition of
Rifamycin S
- rifamycin
- 100722
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate
- Rifamycin Sodium EP Impurity B
- Rifaximin EP Impurity E（Rifamycin EP Impurity B）
- 13553-79-2
- C37H45NO12
- Antibiotics
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
