Tetrachlorvinphos Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R36:Reizt die Augen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
Tetrachlorvinphos was initially registered for use in the United
States in 1966 for use on various food crops, livestock, and pet
animals, and in around buildings. Its use on food crops were
voluntarily canceled in the United States in 1987; however, it is
used on food crops in developing countries. Tetrachlorvinphos
is sold under the trade names Rabon and Gardona.
Chemische Eigenschaften
Technical tetrachlorvinphos is a tan-to-brown crystalline
solid. Tetrachlorvinphos is stable at ,100 C and slowly
hydrolyzed at 50°C. Aromatic odor.
Soluble in water at 24°C 15 ppm; limited
solubility in most aromatic hydrocarbons.
Verwenden
Tetrachlorvinphos is used to control lepidopterous and dipterous
larvae in fruit and lepidopterous larvae in cotton, maize, rice, tobacco and
vegetables. It is also used against nuisance flies in animal houses, animal
ectoparasites and stored product pests.
Hazard
Cholinesterase inhibitor. Questionable carcinogen.
Carcinogenicity
When rats were given diets with
0, 4250, or 8500 ppm tetrachlorvinphos for 80 weeks,
both males and females had a high incidence of thyroid
C-cell hyperplasia, and females had increased incidences of
adrenal cortical adenomas and thyroid C-cell adenomas
.
Environmental Fate
Tetrachlorvinphos is nonpersistent in the environment. The
primary route of dissipation is through biotic degradation.
Based on its use pattern, risks of contamination of groundwater
or surface water by tetrachlorvinphos are minimal.
Stoffwechselwegen
The chemical structure of tetrachlorvinphos is very close to that of
chlorfenvinphos and the routes of metabolic breakdown have been
shown to be very similar. Technical tetrachlorvinphos is usually >95%
Z-isomer, unlike chlorfenvinphos which is an E/Z mixture. As with
chlorfenvinphos, the major routes of detoxification are by dealkylation
and hydrolysis to yield desmethyltetrachlorvinphos and 2,2’,4’,5’-
tetrachloroacetophenone plus dimethyl phosphate, respectively. Further
metabolism of the chloroacetophenone moiety then leads, via reduction
or hydrolysis and glutathione-dependent displacement of the
side chain chlorine substituent, to the formation of 1-(2,4,5-trichlophenyl)
ethane-l,Z-diol and 1-(2,4,5-trichlorophenyl)ethan-l-owl hich are
conjugated with glucose or glucuronic acid to afford the ultimate
metabolites. Oxidation of the β carbon atom to give 2,4,5-trichloromandelic
acid followed by decarboxylation leads to the formation
of 2,4,5-trichlorobenzoic acid which is conjugated with glycine in some
mammals as the final metabolite. The metabolic routes were summarised
by Beynon et al. (1973).
Tetrachlorvinphos Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
