CalciuM polycarbophil

CalciuM polycarbophil Struktur
9003-97-8
CAS-Nr.
9003-97-8
Englisch Name:
CalciuM polycarbophil
Synonyma:
Polycarbophil;CL272;Carbofil;CARBOPOLEX55;Polycarbofil;Policarbofila;Polycarbofil calcico;CALCIUM POLYCARBOPHIL;polycarbophil calcium;Donepezil Impurity 54
CBNumber:
CB21011948
Summenformel:
(C20H18Ca4O18)mult
Molgewicht:
0
MOL-Datei:
Mol file

CalciuM polycarbophil Eigenschaften

Löslichkeit
Polycarbophil polymers do not dissolve in water but can swell in water to around 1000 times their original volume (and ten times their original diameter) to form gels when exposed to a pH environment above 4–6. Since the pKa of these polymers is 6.0±0.5, the carboxylate groups on the polymer backbone ionize, resulting in electrostatic repulsion between the negative particles, which extends the molecule, adding to the swelling of the polymer.
Aggregatzustand
Solid
Farbe
White to off-white

Sicherheit

CalciuM polycarbophil Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Polycarbophil occurs as fluffy, white to off-white, mildly acidic polymer powder with slightly acetic odor.

Verwenden

Benzodiazepine anxiolytic

Vorbereitung Methode

Polycarbophils are synthetic, high-molecular-weight, crosslinked polymers of acrylic acid. These poly(acrylic acid) polymers are crosslinked with divinyl glycol. They are synthesized via precipitation polymerization in ethyl acetate and then dried.

Sicherheit(Safety)

Polycarbophil polymers have a long history of safe and effective use in topical gels, creams, lotions, and ointments. They have been shown to have extremely low irritancy properties and are nonsensitizing with repeated usage.
The use of these polymers is supported by extensive toxicological studies.
(guinea pig, oral): 2.0 g/kg
(mouse, IP): 0.039 g/kg
(mouse, IV): 0.070 g/kg
(mouse, oral): 4.6 g/kg
(rat, oral): >2.5 g/kg
(rabbit, skin): >3.0 g/kg
Chronic oral toxicity No significant effects in rats or dogs were observed after being fed with resin as 5% of the diet for 6? months.

Lager

Polycarbophil polymers are stable, hygroscopic materials. They do not undergo hydrolysis or oxidation under normal conditions. Heat aging at temperatures below 104°C for up to 2 hours does not affect the efficiency of the dry polymer. However, prolonged exposure to excessive temperatures can result in discoloration, reduced stability, and in some cases plasticization of the polymer. Complete decomposition occurs with heating for 30 minutes at 260°C.
Polycarbophil polymers do not support bacteria, mold, or fungal growth in dry powder form. Microbial growth may occur in mucilages of the polymer solution. Although the gel properties are not affected by such growth, this phenomenon is usually unacceptable. The addition of appropriate preservatives prevents mold and bacterial growth in these mucilages. Mucilages and emulsions containing these polymers are stable under freeze–thaw conditions but exposure to high temperatures results in a drop in viscosity.
Polycarbophil polymers are very hygroscopic and should be packed in airtight, corrosion-resistant containers. They should be stored in a cool, dry place, and the container should be kept closed when not in use. Moisture pickup does not affect the efficiency of the resins, but resin containing high levels of moisture is more difficult to disperse and weigh accurately. Glass, plastic, or resinlined containers are recommended for products containing polycarbophil. Packaging in aluminum tubes usually requires formulations to have a pH less than 6.5, and packaging in other metallic tubes or containers necessitates a pH greater than 7.7 to prolong polycarbophil stability.

Inkompatibilitäten

Heat may be generated if polycarbophil comes into contact with strong basic materials such as ammonia, sodium hydroxide, potassium hydroxide, or strongly basic amines. Polycarbophil polymers are not compatible with cationic polymers, strong acids, and high levels of electrolytes, as electrolytes tend to reduce the viscosity of polycarbophil-based gels.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (buccal (tablet) and ophthalmic (solution) preparations; topical patches; vaginal gel). Included in nonparenteral medicines licensed in the UK.

CalciuM polycarbophil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CalciuM polycarbophil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 109)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12829 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 2990 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8816 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

9003-97-8()Verwandte Suche:


  • CARBOPOLEX55
  • Carbofil
  • Policarbofila
  • polycarbophil calcium
  • CALCIUM POLYCARBOPHIL
  • Policarbofila [inn-spanish]
  • Polyacrylic acid calcium salt cross-linked with divinyl glycol
  • Polycarbofil
  • Polycarbofil calcico
  • CalciuM Polycarbophil USP/NFl
  • CL272
  • CalciuM polycarbophil USP/EP/BP
  • Polycarbophil
  • Polycarbophil (9CI, ACI)
  • Donepezil Impurity 54
  • Polycarbonate calcium
  • 9003-97-8
  • C20H18Ca4O18mult
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