Alginsure

Alginic acid Struktur
9005-32-7
CAS-Nr.
9005-32-7
Bezeichnung:
Alginsure
Englisch Name:
Alginic acid
Synonyma:
Sazio;sazzio;Nopgine;kelacid;norgine;Alginsure;landalgine;Alginic aci;Protanal LF;ALGINIC ACID
CBNumber:
CB2145055
Summenformel:
(C6H8O6)n
Molgewicht:
0
MOL-Datei:
Mol file

Alginsure Eigenschaften

Schmelzpunkt:
300 °C
storage temp. 
Room Temperature
Löslichkeit
H2O: insoluble, but swells
Aggregatzustand
Powder
Farbe
White to pale yellow to beige
Geruch (Odor)
wh. to yel. fibrous powd., odorless, tasteless
Optische Aktivität
-141~-146
Wasserlöslichkeit
Insoluble in water.
Sensitive 
Hygroscopic
Merck 
14,242
LogP
-3.203 (est)
CAS Datenbank
9005-32-7
EPA chemische Informationen
Alginic acid (9005-32-7)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 24/25-36-26
WGK Germany  2
RTECS-Nr. AZ5775000
3
TSCA  Yes
HS Code  39131000
Giftige Stoffe Daten 9005-32-7(Hazardous Substances Data)

Alginsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Alginic acid is a tasteless, practically odorless, white to yellowishwhite, fibrous powder.

Verwenden

algin (alginic acid) is used in cosmetic formulations as a thickener, stabilizer, and gelling agent. It is obtained from different varieties of brown seaweed.

Definition

A polysaccharide composed of β,d-mannuronic acid residues linked so that the carboxyl group of each unit is free, while the aldehyde group is shielded by a glycosidic linkage. It is a linear polymer of the mannuronic acid in the pyranose ring form.

Vorbereitung Methode

Alginic acid is a hydrophilic colloid carbohydrate that occurs naturally in the cell walls and intercellular spaces of various species of brown seaweed (Phaeophyceae). The seaweed occurs widely throughout the world and is harvested, crushed, and treated with dilute alkali to extract the alginic acid.

Pharmazeutische Anwendungen

Alginic acid is used in a variety of oral and topical pharmaceutical formulations. In tablet and capsule formulations, alginic acid is used as both a binder and disintegrating agent at concentrations of 1–5% w/w. Alginic acid is widely used as a thickening and suspending agent in a variety of pastes, creams, and gels; and as a stabilizing agent for oil-in-water emulsions.
Alginic acid has been used to improve the stability of levosimendan.
Therapeutically, alginic acid has been used as an antacid.In combination with an H2-receptor antagonist, it has also been utilized for the management of gastroesophageal reflux.

Sicherheitsprofil

Moderately toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes

Sicherheit(Safety)

Alginic acid is widely used in food products and topical and oral pharmaceutical formulations. It is generally regarded as a nontoxic and nonirritant material, although excessive oral consumption may be harmful. Inhalation of alginate dust may be an irritant and has been associated with industrially related asthma in workers involved in alginate production. However, it appears that the cases of asthma were linked to exposure to unprocessed seaweed dust rather than pure alginate dust. An acceptable daily intake of alginic acid and its ammonium, calcium, potassium, and sodium salts was not set by the WHO because the quantities used, and the background levels in food, did not represent a hazard to health.
LD50 (rat, IP): 1.6 g/kg

Lager

Alginic acid hydrolyzes slowly at warm temperatures producing a material with a lower molecular weight and lower dispersion viscosity.
Alginic acid dispersions are susceptible to microbial spoilage on storage, which may result in some depolymerization and hence a decrease in viscosity. Dispersions should therefore be preserved with an antimicrobial preservative such as benzoic acid; potassium sorbate; sodium benzoate; sorbic acid; or paraben. Concentrations of 0.1–0.2% are usually used.
Alginic acid dispersions may be sterilized by autoclaving or filtration through a 0.22 μm filter. Autoclaving may result in a decrease in viscosity which can vary depending upon the nature of any other substances present.
Alginic acid should be stored in a well-closed container in a cool, dry place.

läuterung methode

To 5g of acid in 550mL water containing 2.8g KHCO3 are added 0.3mL of acetic acid and 5g potassium acetate. EtOH is added to make the solution to 25% (v/v) in EtOH, and any insoluble material is discarded. Further addition of EtOH, to 37% (v/v), precipitated alginic acid. Collect the acid and dry it in vacuo. [Pal & Schubert J Am Chem Soc 84 4384 1962.]

Inkompatibilitäten

Incompatible with strong oxidizing agents; alginic acid forms insoluble salts in the presence of alkaline earth metals and group III metals with the exception of magnesium.

Regulatory Status

GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

Alginsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Alginsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 316)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
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sales@amoychem.com China 6383 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58

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