Flumetason
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- CAS-Nr.
- 2135-17-3
- Bezeichnung:
- Flumetason
- Englisch Name:
- Flumethasone
- Synonyma:
- fluvet;FLUCORT;rs-2177;ANIPRIME;anaprime;methagon;NSC-54702;CORTEXILAR;ha-methyl-;umethasone
- CBNumber:
- CB2324823
- Summenformel:
- C22H28F2O5
- Molgewicht:
- 410.45
- MOL-Datei:
- 2135-17-3.mol
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Flumetason Eigenschaften
- Schmelzpunkt:
- 237-240°C
- Siedepunkt:
- 569.8±50.0 °C(Predicted)
- Dichte
- 1.1621 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- acetic acid: soluble10mg/mL
- Aggregatzustand
- solid
- pka
- 11.98±0.70(Predicted)
- Farbe
- white
- Optische Aktivität
- [α]25/D 67.0 to 71.0°, c = 1 in dioxane
- Wasserlöslichkeit
- 1mg/L(20 ºC)
- Merck
- 14,4138
- InChIKey
- WXURHACBFYSXBI-GQKYHHCASA-N
- CAS Datenbank
- 2135-17-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
40 |
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| S-Sätze: |
22-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TU3832000 |
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| HS Code |
29144000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
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Flumetason Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Flumethasone is an agonist of glucocorticoid and mineralocorticoid receptors with EC
50 values of 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors.
In vitro, it inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines at a concentration of 100 nM. Flumethasone (5 mg per animal) decreases tumor necrosis factor (TNF) production
ex vivo in blood cells collected by bronchoalveolar lavage (BAL) from calves with experimentally-induced local lung inflammation. It also inhibits phytohemagglutinin-induced delayed hypersensitivity in calf skin.
In vivo, flumethasone (5 μM) impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in zebrafish.
Chemische Eigenschaften
White Solid
Flumetason Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(6a,11b,16a)-6,9-Difluoro-11-hydroxy-16-methylandrosta-1,4-diene-3,17-dione
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
Fluticasone Impurity
Flumetason Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 424)Lieferanten
2135-17-3(Flumetason)Verwandte Suche:
- 6-alpha,9-alpha-difluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
- 6α,9α-Difluoro-16α-methylprednisolone
- 6α-Fluorodexamethasone
- 6a-Fluoro-dexamethasone, Aniprime, Cortexilar, Flucort
- Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-
- 6α,9α-difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
- FlumethasoneBase98.5%
- (6-alpha,11-beta,16-alpha)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- Flumethazone
- flumetasone
- CORTEXILAR
- FLUCORT
- FLUMETHASONE
- ANIPRIME
- 6a,9a-difluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione
- 6a,9a-difluoro-16a-methylprednisolone
- 6A-FLUORO-DEXAMETHASONE
- 6ALPHA,9ALPHA-DIFLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
- 6ALPHA,9ALPHA-DIFLUORO-16ALPHA-METHYLPREDNISOLONE
- 6ALPHA-FLUORODEXAMETHASONE
- 1,4-PREGNADIEN-6-ALPHA, 9-ALPHA-DIFLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
- anaprime
- flucorticin
- flumethason
- fluvet
- ha-methyl-
- methagon
- rs-2177
- 6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone, 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
- Cortexillar
- NSC-54702
- Flumethasone,6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone
- FluMetahsone
- FULUMETHASONE
- Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
- Flumethasone Solution, 100ppm
- Flumetasone (double dexamethasone)
- Flumethasone, >=99%
- 3-(4-methylpent-3-enyl)-2,5-dihydrothiophene 1,1-dioxide
- lumethasone
- Flumetazone
- Flumethasone sky
- flumetasone cas: 2135-17-3
- 6alpha,9-Difluoro-11beta,17,21-trih
- umethasone
- Pregna-1,4-diene-3,20-dione,6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)-
- Flumethasone USP/EP/BP
- Flumethasone 2135-17-3
- Flumetasone pivalate EP Impurity A
- Flumethasone (Flumetasone)
- 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione (Flumetasone)
- (6S,8S,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
- 1, 4-PREGNADIEN-6α, 9α-DIFLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
- C13718500 Flumethasone
- Flumethasone in Acetonitrile
- 2135-17-3
- C22H28F2O5
