Galantaminhydrobromid
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- CAS-Nr.
- 1953-04-4
- Bezeichnung:
- Galantaminhydrobromid
- Englisch Name:
- Galantamine Hydrobromide
- Synonyma:
- GALANTHAMINE HYDROBROMIDE;GALANTAMINE HBR;GALANTHAMINE HBR;NIVALIN;4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide;NIVALIN, HBR;Galanthamine HCI;GALANTAMINE HYDROBROMIDE;GALANTHAMIDE HYDROBROMIDE
- CBNumber:
- CB2439815
- Summenformel:
- C17H22BrNO3
- Molgewicht:
- 368.27
- MOL-Datei:
- 1953-04-4.mol
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Galantaminhydrobromid Eigenschaften
- Schmelzpunkt:
- 256 °C
- alpha
- D20 -93.1° (c = 0.1015 in 15 ml H2O)
- Brechungsindex
- -95 ° (C=1.4, H2O)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
- Aggregatzustand
- White to off-white crystalline solid.
- Farbe
- White to Orange to Green
- Wasserlöslichkeit
- Soluble in water or DMSO
- Merck
- 14,4340
- InChI
- InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
- InChIKey
- QORVDGQLPPAFRS-ORFATOSYNA-N
- SMILES
- [C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r|
- LogP
- 1.750 (est)
- CAS Datenbank
- 1953-04-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
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| R-Sätze: |
25 |
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| S-Sätze: |
45-36/37/39-22 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DF8075000 |
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| HazardClass |
6.1 |
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| PackingGroup |
II |
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| HS Code |
29399990 |
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| Toxizität |
LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Galantaminhydrobromid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
Galantamine hydrobromide is a white to almost white powder and is sparingly soluble in water.
Verwenden
Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Galantamine Hydrobromide, a reversible, competitive acetyl cholinesterase inhibitor, is suggested for the remedy of mild to moderate dementia of the Alzheimer′s type.
Biologische Aktivität
Long-acting, centrally active acetylcholinesterase inhibitor (IC 50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β -amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Galantaminhydrobromid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Galantaminhydrobromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 413)Lieferanten
1953-04-4(Galantaminhydrobromid)Verwandte Suche:
4-Methoxyphenylessigsäure
2-Methoxybenzaldehyd
4-Methoxybenzylalkohol
Hydrogenbromid
HYOSCINE N BUTYL BROMIDE BP
Dextromethorphan hydrobromide monohydrate
Anisaldehyd
Anisol
p-Anissure
3-Methoxybenzylalkohol
(Trifluormethoxy)benzol
(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Benzolessigsäure, alpha-(hydroxymethyl)-9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl-ester, (7(S)-(1 alpha, 2 beta,4 beta, 5 alpha, 7 beta))-hydrobromid
Cyclohex-2-en-1-ol
3-tert-Butylphenol
Wasserstoff
Galantaminhydrobromid
- (-)-Galanthaminium bromide
- Hydrobromic acid·galanthamine
- galanthamine hydrobromide from lycoris sp.
- Galanthamine Hydrobromide Injection
- GALANTHAMINE HYDROBROMIDUM
- Lycorisradiata（l'.aher.)herb
- Galanthamine hydrobromide from Lycoris sp.,Galantamine hydrobromide
- Galantamine Hydrobromide (200 mg)
- GALANTHAMINE HYDROBROMIDE(P)
- 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide
- Galanthamine hydrobromide, >=99%
- Galanthamine hydrobromide 99.7%
- galantamine HBr 8% pellets
- GALANTHAMIDE HYDROBROMIDE
- NIVALIN, HBR
- GALANTAMINE HYDROBROMIDE
- Galantamine Hydrobromide Lycoremine 1953-04-4
- Galanthamine HCI
- GalantamineHydrobromide>
- Galantamine racemic mixture CRS
- Galantamine synthetic for system suitability CRS
- Galantamine Hydrobromide,>98%
- (4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol hydrobromide
- Galantamine Hydrobromide USP/EP/BP
- Galantamine Hydrobromide extrapure, 98%
- Galantamine Hydrobromide (1287755)
- GALANTAMINE HBR
- 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE
- NIVALIN
- GALANTHAMINE HYDROBROMIDE
- GALANTHAMINE HBR
- (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide
- 1953-04-4
- 4/4/1953
- 19-45-3
- C17H22BrNO3
- C17H21NO3HBr
- C17H21NO3xHBr
- C17H21NO3HBrC17H22BrNO3
- C17H22NO3Br
- Alkaloids (Others)
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors
- Cholinesterase
- A to C
- BioChemical
- Biochemicals and Reagents
- Alkaloids
- Reminyl
- Other APIs
- API
- Chiral Reagents
- Pharmaceutical intermediates
- Alkaloids
- Alkaloids (Others)
- Biochemistry
- Functional Products
