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koumine

koumine Struktur
1358-76-5
CAS-Nr.
1358-76-5
Englisch Name:
koumine
Synonyma:
koumine;Koumine-RM;(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan;7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-;(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
CBNumber:
CB31480541
Summenformel:
C20H22N2O
Molgewicht:
306.4
MOL-Datei:
1358-76-5.mol
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koumine Eigenschaften

Schmelzpunkt:
168℃
Siedepunkt:
436.5±45.0 °C(Predicted)
Dichte
1.42
storage temp. 
2-8°C
Löslichkeit
DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic)
Aggregatzustand
powder
pka
8.67±0.40(Predicted)
Farbe
Yellow-brown

Sicherheit

koumine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).

Occurrence

Koumine is an alkaloid isolated from Gelsemium elegans Benth.

Verwenden

Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.

Einzelnachweise

Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938)

koumine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

koumine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 167)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd. 		18017610038
zheyansh@163.com CHINA 3619 58
Chengdu Greenpure Biopharma CO.,Ltd 		18283602253; +8618283602253
 jancyzheng@gcgreenpure.com China 953 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083
 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897
 sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Shaanxi Pioneer Biotech Co., Ltd . 		+8613259417953
 sales@pioneerbiotech.com China 3000 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Shanghai Standard Technology Co., Ltd. 		18502101150
ft-sales@nature-standard.com CHINA 1923 58

1358-76-5()Verwandte Suche:

4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat (R*,R*)-(+)-9,9',10,10'-Tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo[9,9'-bianthracen]-2,2'-dicarbonsure Methyl-(2α,5β,6α)-3,4-didehydroibogamin-18β-carboxylat Vincristin Chenodesoxycholsure Cianidanol
  • koumine
  • (3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan
  • 7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-
  • 6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
  • (3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole
  • Koumine-RM
  • 1358-76-5
  • 58-76-5
  • Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
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