Sulfaphenazol

SULFAPHENAZOLE Struktur
526-08-9
CAS-Nr.
526-08-9
Bezeichnung:
Sulfaphenazol
Englisch Name:
SULFAPHENAZOLE
Synonyma:
SP;TFF2;Sulfabid;Sulfaphenazol;Sulphaphenazole;Sulfaphenylpyrazole;SML1;Orisul;Inamil;Isarol
CBNumber:
CB4160540
Summenformel:
C15H14N4O2S
Molgewicht:
314.36
MOL-Datei:
526-08-9.mol

Sulfaphenazol Eigenschaften

Schmelzpunkt:
179-183 °C
Siedepunkt:
541.9±56.0 °C(Predicted)
Dichte
1.39
Brechungsindex
1.6440 (estimate)
storage temp. 
2-8°C
Löslichkeit
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
pKa 5.71(H2O t = 25 I = 0.05) (Uncertain)
Farbe
white to light yellow

Sicherheit

S-Sätze: 24/25
WGK Germany  2
RTECS-Nr. DA9520000
HS Code  29339900
Toxizität LD50 orally in mice: 5800 mg/kg (Seki)

Sulfaphenazol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Kis = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

Chemische Eigenschaften

White to off-white powder

Definition

ChEBI: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.

läuterung methode

Crystallise it from EtOH or aqueous EtOH. [Schmidt & Druey Helv Chim Acta 41 309 1958, Beilstein 25 III/IV 2029.]

Sulfaphenazol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sulfaphenazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 176)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32820 60
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32024 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 23325 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15361 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
info@finetechnology-ind.com China 9640 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38463 58

526-08-9(Sulfaphenazol)Verwandte Suche:


  • LABOTEST-BB LT00772280
  • 4-AMINO-N-(1-PHENYL-1H-PYRAZOL-5-YL)BENZENESULFONAMIDE
  • n(sup1)-(1-phenylpyrazol-5-yl)sulfanilamide
  • n’-(1-phenylpyrazol-5-yl)sulfanilamide
  • N1-(1-Phenylpyrazol-5-yl)sulfanilamide
  • Orisul
  • Orisulf
  • Paidazolo
  • Plisulfan
  • Raziosulfa
  • Sulfafenazolo
  • Sulfanilamide, N1-(1-phenylpyrazol-5-yl)-
  • Sulfaphenazon
  • Sulfaphenylpipazol
  • Sulphenazole
  • SULFAPHENAZOLE
  • Eftolan
  • Sulfiam
  • 4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide
  • 4-azanyl-N-(2-phenylpyrazol-3-yl)benzenesulfonamide
  • Sulfaphenazole ,99%
  • Sulfaphenazole,4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
  • N1-(1-phenylpyrazol-5-yl)sulphanilamide
  • SULFAPHENZAOLE
  • N1-(1-Phenylpyrazol-5-yl)sulfanilamide
  • Sulfaphenazole Solution, 100ppm
  • pS2 protein
  • 1-Phenyl-5-sulfanilamidopyrazole
  • 3-(p-Aminobenzenesulfonamido)-2-pheny-2H-lpyrazole
  • 3-(p-aminobenzenesulfonamido)-2-phenylpyrazole
  • 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)-benzenesulfonamid
  • 5-Sulfanilamido-1-phenylpyrazole
  • Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-
  • Depocid
  • Depotsulfonamide
  • Eftolon
  • Firmazolo
  • Inamil
  • Isarol
  • Isarol V
  • Merian
  • Microtan pirazolo
  • microtanpirazolo
  • N'-(1-Phenylpyrazol-5-yl)sulfanilamide
  • n(sup1)-(1-phenylpyrazol-5-yl)-sulfanilamid
  • TFF-2 human
  • Trefoil Factor peptide
  • SML1
  • Spasmolytic polypeptide
  • Trefoil factor 2
  • 4-amino-N-(2-phenyl-3-pyrazolyl)benzenesulfonamide
  • N1-(1-Phenylpyraz
  • Sulfaphenazole - Depocid | Depotsulfonamide | Plisulfan | Raziosulfa
  • aesculi
  • coniospora
  • sp. JSM071073
  • sp. L-1
  • sp. S13
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