Dimenhydrinat

Dimenhydrinate Struktur
523-87-5
CAS-Nr.
523-87-5
Bezeichnung:
Dimenhydrinat
Englisch Name:
Dimenhydrinate
Synonyma:
emes;epha;gravol;vomexa;dramyl;dromyl;emedyl;faston;DiMate;amosyt
CBNumber:
CB4308768
Summenformel:
C17H21NO.C7H7ClN4O2
Molgewicht:
469.97
MOL-Datei:
523-87-5.mol

Dimenhydrinat Eigenschaften

Schmelzpunkt:
102-107°C
Dichte
1.2586 (rough estimate)
Brechungsindex
1.6500 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
Slightly soluble in water, freely soluble in ethanol (96 per cent).
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserlöslichkeit
Slightly soluble (0.1-1 g/100 mL at 22 ºC)
Stabilität:
Hygroscopic
InChIKey
NFLLKCVHYJRNRH-UHFFFAOYSA-N
CAS Datenbank
523-87-5(CAS DataBase Reference)
EPA chemische Informationen
Dimenhydrinate (523-87-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 22-61-36/37/38
S-Sätze: 22-26-36/37/39-53
WGK Germany  3
RTECS-Nr. XH5082000
TSCA  Yes
HS Code  2939590000
Giftige Stoffe Daten 523-87-5(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

Dimenhydrinat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R61:Kann das Kind im Mutterleib schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.

Beschreibung

Dimenhydrinate (16.1.2) is a complex compound of N, N-dimethyl (2- diphenylmethoxy)ethylamine—diphenhydramine with 8-chlorotheophylline. While blocking the H1 receptor, dimenhydrinate simultaneously acts on the vomiting center.

Chemische Eigenschaften

White Solid
Dimenhydrinate is freely soluble in ethanol and chloroform, slightly soluble in water, and almost in-soluble in ether.

Verwenden

Dimenhydrinate is used for preventing and stopping sea or airsickness, and for nausea and vomiting. Synonyms of this drug are dramamine, dadalon, emedyl, travelin, and others.

Definition

ChEBI: The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention nd treatment of motion sickness.

Allgemeine Beschreibung

The 8-chlorotheophyllinate (theoclate) salt of diphenhydramine, 8-chlorotheophylline 2-(diphenylmethoxy)-N,N-dimethylethylamine (Dramamine), is a white crystalline, odorless powder that is highly soluble in water and freely soluble in alcohol and chloroform. Dimenhydrinate is recommended for nausea of motion sickness and for hyperemesis gravidarum (nausea of pregnancy).

Air & Water Reaktionen

Slightly soluble in water. Slightly acidic.

Health Hazard

SYMPTOMS: Symptoms associated with Dimenhydrinate include: drowsiness, lethargy, fatigue hypnosis and coma. Initial sedation may be followed by central nervous system hyperexcitability. Also, the victim may experience dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, and/or diarrhea.

Brandgefahr

Flash point data for Dimenhydrinate are not available but Dimenhydrinate is probably non-flammable.

Sicherheitsprofil

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. A drug much used for motion sickness. Human systemic effects by ingestion: arrhythmias, convulsions, distorted perceptions, hallucinations, intracranial pressure increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. See also AMINES.

Dimenhydrinat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dimenhydrinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 239)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 742 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2524 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29815 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12829 58

523-87-5(Dimenhydrinat)Verwandte Suche:


  • gravinol
  • gravol
  • lmethoxy)-n,n-dimethylethanamine(1:1)
  • menhydrinate
  • methoxy)-n,n-dimethylethanamine(1:1)
  • n,n-dimethyl-2-(diphenylmethoxy)-ethylamincompd.with8-chlorotheophylli
  • n,n-dimethyl-2-diphenylmethoxyethylamine8-chlorotheophyllinate
  • nci-c60639
  • n-dimethyl-ethylamine2-(diphenylmethoxy)-compdwith8-chlorotheophylline(
  • neo-navigan
  • novamine
  • o-benzhydryldimethylaminoethanol8-chlorotheophyllinate
  • permital
  • reidamine
  • reise-engletten
  • removine
  • supremal
  • teodramin
  • theophylline,8-chloro-,compd.with2-(diphenylmethoxy)-n,n-dimethylethylamine
  • theophylline,8-chloro-,compdwith2-(diphenylmethoxy)-n,n-dimethyethylamine(
  • travelin
  • travelmin
  • vomexa
  • xamamina
  • diphenhydramine8-chlorotheophyllinate
  • diphenhydramine8-chlorotheophylline
  • Diphenhydramineteoclate
  • diphenhydrinate
  • dramamin
  • dramarin
  • dramyl
  • dromyl
  • eldodram
  • emedyl
  • emes
  • epha
  • faston
  • DRAMAMINE
  • DIMENHYDRINATE
  • THEOHYDRAMINE
  • N-[2-DIPHENYLMETHOXYETHYL]-N,N-DIMETHYLAMMONIUM 8-CHLORO-THEOPHYLLINATE
  • 2-(benzhydryloxy)-n,n-dimethylethylamine 8-chlorotheophyllinate
  • 8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione compound with 2-(diphenylmethoxy)-n,n-dimethylethanamine (1:1)
  • 2-(benzhydryloxy)-n,n-dimethylethylaminecompd.with8-chlorotheophylline
  • 2-(diphenylmethoxy)-n,n-dimethylethylamine8-chlorotheophyllinate
  • Dimenhydrinate,Usp
  • 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
  • DIMENHYDRINAT
  • DIMENHYDRATE
  • DIMENHYDRINATE[N-(2-DIPHENYLMETHOXYETHYL)-N,N-DIMETHYLAMMONIUM 8-CHLOROTHEOPHYLLINATE]
  • 8-Chlorotheophylline 2-(DiphenylMethoxy)-N,N-diMethylethylaMine
  • DiMate
  • DoMManate
  • DraMocen
  • Gravinol (antieMetic)
  • NSC 117855
  • Travel-GuM
  • 8-chloro-1,3-diMethyl-1H-purine-2,6(3H,7H)-dione coMpound with 2-(benzhydryloxy)-N,N-diMethylethanaMine (1:1)
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