Ethyl 2-chloronicotinate
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- CAS-Nr.
- 1452-94-4
- Englisch Name:
- Ethyl 2-chloronicotinate
- Synonyma:
- AVAC-001;oronicotinate;Ethyl 2-chloronicoti;Flunixin EP Impurity C;ETHYL 2-CHLORONICOTINATE;ethy-2-chloroisonicoitate;Ethyl2-Chloronicotinate>Flunixin Related CoMpound C;Ethyl2-chloronicotinate,98%;Flunixin Meglumine Impurity C
- CBNumber:
- CB4312224
- Summenformel:
- C8H8ClNO2
- Molgewicht:
- 185.61
- MOL-Datei:
- 1452-94-4.mol
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Ethyl 2-chloronicotinate Eigenschaften
- Schmelzpunkt:
- 68 C
- Siedepunkt:
- 78°C (0.1 mmHg)
- Dichte
- 1.2445 g/cm3(Temp: 25 °C)
- Brechungsindex
- 1.5210-1.5250
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.32±0.10(Predicted)
- Farbe
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3
- InChIKey
- PMIMPBYTPPRBGD-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C(OCC)=O
- CAS Datenbank
- 1452-94-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Ethyl 2-chloronicotinate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Light yellow liquid
Verwenden
Ethyl 2-chloronicotinate,is used as a pharmaceutical intermediate.
Synthesis Reference(s)
Tetrahedron, 51, p. 13177, 1995
DOI: 10.1016/0040-4020(95)00788-A
Synthese
2-Chloropyridine-3-carboxylic acid (7.9 g) and thionyl chloride (45 ml) were heated for 3 hours in benzene (65 ml) under reflux. The reaction mixture was concentrated to leave an oil, which was added dropwise to ethanol (40 ml). The mixture was heated for a further one hour under reflux. The solvent was distilled, and the residue was dissolved in toluene. The solution was dried over anhydrous magnesium sulfate. The solvent was distilled to leave Ethyl 2-chloronicotinate (8.4 g, 90%) as a pale yellow oil.
Ethyl 2-chloronicotinate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ethyl 2-chloronicotinate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 308)Lieferanten
1452-94-4()Verwandte Suche:
- ETHYL 2-CHLORONICOTINATE
- ethyl 2-chloropyridine-3-carboxylate
- 2-CHLORONICOTINIC ACID ETHYL ESTER
- 2-Chloro-3-pyridinecarboxylic acid ethyl ester
- 2-Chloropyridine-3-carboxylic acid ethyl ester
- Ethyl 2-chloronicoti
- Ethyl 2-Chloro-3-pyridinecarboxylate
- 2-Chloronicotinic Acid Ethyl Ester
Ethyl 2-Chloro-3-pyridinecarboxylate
2-Chloro-3-pyridinecarboxylic Acid Ethyl Ester
- 2-Chloronicotinate ethyl ester
- Ethyl 2-chloropyridine-3-carboxylate, 2-Chloro-3-(ethoxycarbonyl)pyridine
- Flunixin Related CoMpound C
- Ethyl 2-chloronicotinate, 99%, 99%
- Ethyl2-chloronicotinate,98%
- AVAC-001
- oronicotinate
- Flunixin Meglumine Impurity 3（Flunixin Meglumine EP Impurity C）
- Flunixin Meglumine EP Impurity C
- Ethyl2-Chloronicotinate>
- Ethyl 2-Chloropyridine-3-carboxylat
- Flunixin EP Impurity C
- Flunixin impurity CQ: What is
Flunixin impurity C Q: What is the CAS Number of
Flunixin impurity C Q: What is the storage condition of
Flunixin impurity C Q: What are the applications of
Flunixin impurity C
- Flunixin Related Compound C (Ethyl 2-chloronicotinate) (1274631)
- Flunixin USP Related Compound C
- ethy-2-chloroisonicoitate
- Flunixin Meglumine Impurity C
- 1452-94-4
- C8HBCINO2
- pyridine series
- Pyridines
- Pharmaceutical Intermediates
- Pyridine
- Fluorobenzene
