oelsure, Monoester mit Glycerin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
§ 184.1323(a) Glyceryl monooleate is prepared by esterification of
commercial oleic acid that is derived either from edible sources
or from tall oil fatty acids meeting the requirements of §172.862.
It contains glyceryl monooleate (C21H40O4 and glyceryl esters of
fatty acids present in commercial oleic acid.
Chemische Eigenschaften
Colourless Solid
Verwenden
93% 1-Oleoyl, 7% 2-oleoyl
Vorbereitung Methode
Glyceryl monooleate is prepared by the esterification of glycerol
with fatty acids, chiefly oleic acid. As the fatty acids are not pure
substances, but rather a mixture of fatty acids, the product obtained
from the esterification will contain a mixture of esters, including
stearic and palmitic. Di- and triesters may also be present. The
composition and, therefore, the physical properties of glyceryl
monooleate may thus vary considerably from manufacturer to
manufacturer; e.g. the melting point may vary from 10–35°C.
Definition
An antifog agent and dispersant.
Pharmazeutische Anwendungen
Glyceryl monooleate is a polar lipid that swells in water to give
several phases with different rheological properties. It is available
in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the
self-emulsifying grade containing about 5% of an anionic surfactant.
The nonemulsifying grade is used in topical formulations as an
emollient and as an emulsifying agent for water-in-oil emulsions. It
is also a stabilizer for oil-in-water emulsions. The self-emulsifying
grade is used as a primary emulsifier for oil-in-water systems.
Glyceryl monooleate gels in excess water, forming a highly
ordered cubic phase that can be used to sustain the release of
various water-soluble drugs.It is also the basis of mucoadhesive
drug delivery systems.
Glyceryl monooleate is reported to enhance transdermal and
buccal penetration.
Sicherheitsprofil
When heated to
decomposition it emits acrid smoke and irritating fumes.
Sicherheit(Safety)
Glyceryl monooleate is used in oral and topical pharmaceutical
formulations and is generally regarded as a relatively nonirritant
and nontoxic excipient.
Lager
Glyceryl monooleate should be stored in an airtight container,
protected from light in a cool, dry place.
Inkompatibilitäten
Glyceryl monooleate is incompatible with strong oxidizing agents.
The self-emulsifying grade is incompatible with cationic surfactants.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database
(oral capsules, oral powder, oral tablets; creams, controlled-release
transdermal films). Included in nonparenteral medicines licensed in
the UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
oelsure, Monoester mit Glycerin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
