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Irinotecan hydrochloride trihydrate

Irinotecan hydrochloride trihydrate Struktur
136572-09-3
CAS-Nr.
136572-09-3
Englisch Name:
Irinotecan hydrochloride trihydrate
Synonyma:
Iriontecan HCL;Irinotecan HCL 3H2O;Irinotecan HydrochL;Irinotecan Trihydrate;CPT-11 HCl Trihydrate;Irinotecan Hydrochlorid;IRINOTECON HCL TRIHYDRATE;IRINOTECAN HCL TRIHYDRATE;Irinotecan HCI Trihydrate;trihydrate,(s)-hydrochlorid
CBNumber:
CB6122430
Summenformel:
C33H45ClN4O9
Molgewicht:
677.18
MOL-Datei:
136572-09-3.mol
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Irinotecan hydrochloride trihydrate Eigenschaften

Schmelzpunkt:
250-256°C (dec.)
Siedepunkt:
257°C(lit.)
storage temp. 
2-8°C
Löslichkeit
Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
Aggregatzustand
White solid.
Farbe
Yellow
Wasserlöslichkeit
Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck 
14,5091
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
CAS Datenbank
136572-09-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 22
S-Sätze: 20/21-22
RTECS-Nr. DW1060750
HS Code  29349990
Toxizität dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H372 Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P314 Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.
P330 Mund ausspülen.
P403 An einem gut belüfteten Ort aufbewahren.

Irinotecan hydrochloride trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White powder

Verwenden

Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.

Definition

ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

Hazard

Moderately toxic by ingestion.

Irinotecan hydrochloride trihydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Irinotecan hydrochloride

Downstream Produkte

Irinotecan hydrochloride trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 482)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12829 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-17333973358
 sales06@hbduling.cn China 8054 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +8613675893055
 info@hyper-chem.com China 295 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9220 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
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 sales@sdzschem.com China 2930 58
Hainan Xiyuan Chemical Technology Co., Ltd. 		+86-15008981366
15008981366@163.com CHINA 9 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58

136572-09-3()Verwandte Suche:

Cisplatin Fluoruracil Mesna
  • Irinotecan-d10 hydrochloride trihydrate
  • CPT-11 HCl Trihydrate
  • irinotecan hydrochloride hydrate
  • Irinotecanhydrochloridetrihydrate(CPT-11)
  • IRINOTECON HCL TRIHYDRATE
  • [1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE
  • (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%
  • Irinotecan Hydrochloride (100 mg)
  • Irinotecan Hydrochloride 
  • Irinotecan Trihydrate
  • [1,4'-Bipiperidine]-1'-carboxylicacid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-ylester,hydrochloride,hydrate(1:1:3)
  • Irinotecan HCl Trihydrate (CaMpto)
  • Irinotecan, Hydrochloride Salt, Trihydrate
  • Irinotecan hydrochloride trihydrate, >=99%
  • (1,4’-bipiperidine)-1’-carboxylicacid,4,11-diethyl-3,4,12,14-tetrahydro-4-hyd
  • roxy-3,14-dioxo-1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinolin-9-ylester,mono
  • trihydrate,(s)-hydrochlorid
  • IRINOTECAN HYDROCHLORIDE TRIHYDRATE
  • IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE
  • IRINOTECAN HCL TRIHYDRATE
  • Irinotecan HCL 3H2O
  • rinotecan hydrochloride trihydrate
  • (s)-[1,4'-bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
  • Irinotecan Hydrochlorid
  • 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin Hydrochloride Trihydrate
  • Irinotecan hydrochloride trihydrate CRS
  • Irinotecan for peak identification
  • Irinotican Hydrochloride Trihydrate
  • IrinotecanHydrochlorideTrihydrate>
  • Irinotecan HydrochL
  • Irincan hydrochloride trihydrate
  • Irinotecan hydrochloride trihydrate USP/EP/BP
  • Irinotican Hydrochloride TrihydrateQ: What is Irinotican Hydrochloride Trihydrate Q: What is the CAS Number of Irinotican Hydrochloride Trihydrate Q: What is the storage condition of Irinotican Hydrochloride Trihydrate Q: What are the applications of Irinotican Hydrochloride Trihydrate
  • Irinotecan for peak identification (Y0001831)
  • Irinotecan for system suitability 1 (Y0001830)
  • Irinotecan for system suitability 2 (Y0001833)
  • Irinotecan Hydrochloride (1347609)
  • Irinotecan hydrochloride trihydrate (Y0001832)
  • Iriontecan HCL
  • CPT 11; CAMPTOSAR; CAMPTO; IRINOTECAN
  • Irinotecan HCI Trihydrate
  • (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
  • Irinotecan hydrochloride trihydrate 98%
  • (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl [1,4’-Bipiperidine]-1’-carboxylate Hydrochloride Trihydrate
  • Irinotecan (CPT-11) HCl Trihydrate
  • (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
  • (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl [1,4’-Bipiperidine]-1’-carboxylate Hydrochloride Trihydrate
  • 136572-09-3
  • 6572-09-3
  • 36572-09-3
  • C33H38N4O6HCl3H2O
  • C33H38N4O6ClH3H2O
  • C33H45ClN4O9
  • Inhibitors
  • Anticancer
  • Anti-cancer&immunity
  • API
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