5-(Aminomethyl)-3(2H)isoxazolon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
The amino acid γ-
aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-
gated ion channels, GABA
A and GABA
C and a G protein-
coupled receptor, GABA
B. Muscimol is a full GABA
A agonist and partial GABA
C agonist. It binds GABA
A on both high-
and low-
affinity sites (K
d = 10 and 270 nM, respectively), stimulating chloride efflux with an EC
50 value of 200 nM. Benzodiazepines enhance the effects of muscimol
via GABA
A without altering its binding. Muscimol activates GABA
C receptors with an EC
50 value of 1.3 μM. It also acts as an inhibitor of GABA
A uptake and a substrate for the GABA-
metabolizing enzyme GABA transaminase. Muscimol impairs memory formation and retrieval in mice and attenuates airway constriction in guinea pigs
in vivo.
Chemische Eigenschaften
Tan Solid
Verwenden
A potent but toxic structural analogue of g-aminobutyric acid (GABA), with a zwitterionic structure that can cross the blood-brain barrier
Definition
ChEBI: A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Allgemeine Beschreibung
Crystals. Formerly used as a sedative and an anti-emetic.
Reaktivität anzeigen
MUSCIMOL is a ketone and an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides
Health Hazard
MUSCIMOL is a natural constituent of amanita mushrooms and is extremely toxic. It is a potent central nervous system depressant, and is believed to be responsible for most of the nervous system effects that result from eating this mushroom. The lowest toxic dose in humans has been reported at 109 mg/kg.
Brandgefahr
When heated to decomposition, MUSCIMOL emits toxic fumes of nitrogen oxides.
Biologische Aktivität
Potent GABA A receptor agonist and partial GABA C receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo .
läuterung methode
Recrystallise muscimol from MeOH/tetrahydrofuran or EtOH and sublime it at 110-140o (bath) at 10-4 mm to give a yellow spot with ninhydrin which slowly turns purple [NMR: Bowden et al. J Chem Soc (C) 172 1968]. It can also be purified by dissolving in the minimum volume of hot H2O and adding EtOH dropwise until cloudy, cool, and colourless crystals separate; IR: max 3445w, 3000-2560w br, 2156w, 1635s and 1475s cm-1. [NMR: Jager & Frey Justus Liebigs Ann Chem 817 1982.] Alternatively it has been purified by two successive chromatographic treatments on Dowex-1 x 8, with the first elution with 2M AcOH and a second with a linear gradient between 0—2M AcOH, evaporating the desired fractions and recrystallising the residue from MeOH. [McCarry & Savard Tetrahedron Lett 22 5153 1981, Nakamura Chem Pharm Bull Jpn 19 46 1971.]
5-(Aminomethyl)-3(2H)isoxazolon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
