Mosapride citrate
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- CAS-Nr.
- 112885-42-4
- Englisch Name:
- Mosapride citrate
- Synonyma:
- as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapridecitrate/TAK-370citrate/AS-4370citrate
- CBNumber:
- CB6696030
- Summenformel:
- C27H33ClFN3O10
- Molgewicht:
- 614.02
- MOL-Datei:
- 112885-42-4.mol
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Mosapride citrate Eigenschaften
- Schmelzpunkt:
- 143-145°
- storage temp.
- Inert atmosphere,2-8°C
- Löslichkeit
- DMSO (Slightly), Ethanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Stabilität:
- Hygroscopic
- CAS Datenbank
- 112885-42-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Toxizität |
LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitsschädlich bei Einatmen. |
Akute Toxizität inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P310 |
Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen. |
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Mosapride citrate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT
4 (K
i = 69.9 nM). It is selective for 5-HT
4 over 5-HT
1, 5-HT
2, dopamine D
2, and α
1- and α
2-adrenergic receptors but acts as a partial antagonist at 5-HT
3 (K
i = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC
50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.
Verwenden
As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.
Biologische Aktivität
5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
Mosapride citrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Mosapride citrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 280)Lieferanten
112885-42-4()Verwandte Suche:
- 4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE
- 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate
- Gasmotin
- enzamidecitrate
- yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1)
- 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate
- 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
- 4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
- Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate
- 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate
- MOSAPRIDE CITRATE
- (+-)-4-amino-5-chloro-2-ethoxy-n-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)b
- as4370
- benzamide,4-amino-5-chloro-2-ethoxy-n-((4-((4-fluorophenyl)methyl)-2-morpholin
- AS-4370 citrate
- TAK-370 citrate
- Mosapride citrate,>99%
- Mosapride citrate USP/EP/BP
- Mosapride Citrate
DISCONTINUED PLEASE SEE M730995
- Mosapride Citrate (TAK-370
- Mosapride CitrateQ: What is
Mosapride Citrate Q: What is the CAS Number of
Mosapride Citrate Q: What is the storage condition of
Mosapride Citrate Q: What are the applications of
Mosapride Citrate
- Mosapridecitrate/TAK-370citrate/AS-4370citrate
- 112885-42-4
- C21H25ClFN3O3C6H8O7C
- C21H25ClFN3O3C6H8O72H20
- C21H25ClFN3O3C6H8O72H2O
- C21H25ClFN3O3C6H8O7
- C21H25ClFN3O3C6H8O7C27H33ClFN3O10
- C27H33ClFN3O10
- Inhibitors
- APIS
- API
- TAK-370, AS-4370, Gasmotin
- Gastroprokinetic Agent
