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GRAMICIDIN C

GRAMICIDIN C Struktur
113-73-5
CAS-Nr.
113-73-5
Englisch Name:
GRAMICIDIN C
Synonyma:
GRAMICIDIN S;Gramicidin S-A;GRAMICIDIN C;Gramicidin S1;Soviet Gramicidin C;Cyclo(L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-);Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-);HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-PHE-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH
CBNumber:
CB6759311
Summenformel:
C60H92N12O10
Molgewicht:
1141.45
MOL-Datei:
113-73-5.mol
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GRAMICIDIN C Eigenschaften

Schmelzpunkt:
265-270 °C (decomp)(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
Siedepunkt:
827.42°C (rough estimate)
Dichte
1.0265 (rough estimate)
Brechungsindex
1.6000 (estimate)
pka
13.00±0.70(Predicted)
Wasserlöslichkeit
0.14g/L(28 ºC)
InChIKey
IUAYMJGZBVDSGL-XNNAEKOYSA-N

Sicherheit

GRAMICIDIN C Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Gramicidin S was found in the culture broth of Bacillus brevis by Gause of the USSR Academy of Medical Sciences in 1944. It was later found by Otani of Osaka University in the cells of the Nagano strain of the same species. The antibiotic is a basic peptide showing strong activity against gram-positive bacteria and considerable activity against gramnegative cocci and Mycobacterium. Gramicidin S is rather toxic but is not absorbed orally; it is used topically as an ointment or as eye or ear drops in combination with other antibacterial drugs.

Definition

A cyclic peptide that acts on gram-positive bacteria.

läuterung methode

Gramicidin S crystallises from EtOH. The di-HCl crystallises from EtOH (+ few drops of HCl) with m 277-278o (see below). [NMR: Gibbons et al. Nature 227 840 1970, Beilstein 26 III/IV 4273.]

GRAMICIDIN C Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Benzol Pentan Aceton Ethanol 2,2,2-Trichlorethanol

Downstream Produkte

GRAMICIDIN C Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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113-73-5()Verwandte Suche:

Bacitracin Gramicidin D Gramicidin
  • GRAMICIDIN C
  • HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-PHE-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH
  • Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-)
  • Cyclo(L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-)
  • Gramicidin S1
  • Soviet Gramicidin C
  • GRAMICIDIN S
  • Gramicidin S-A
  • 113-73-5
  • C60H92N12O10
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