ignavine

ignavine Struktur
1357-76-2
CAS-Nr.
1357-76-2
Englisch Name:
ignavine
Synonyma:
ignavine;Hetisan-2α,3β,9,15β-tetrol 2-benzoate;Hetisan-2,3,9,15-tetrol, 2-benzoate, (2α,3β,15β)- (9CI)
CBNumber:
CB71342456
Summenformel:
C27H31NO5
Molgewicht:
449.54
MOL-Datei:
1357-76-2.mol

ignavine Eigenschaften

Schmelzpunkt:
226-8°C

Sicherheit

Toxizität LD50 oral in mouse: > 500mg/kg

ignavine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

This aconitine alkaloid is present in several A conitum species indigenous to Japan, e.g. Aconitum calliantum Koidzumi, A. grossedentatum, Nakai, A. hakusanense Nakai, A. kamtschaticum Willd. et Reichb., A. lucidusculum Nakai, A. senanense Nakai, A. subcuneatum Nakai, A. tortuosum Willd. and A. Zuccarini Nakai. It yields clusters of colourless needles when crystallized from Me2COMeOH and gives a form, m.p. 172-4 °c in addition to the one having the above melting point. It is dextrorotatory with [α]29D~} + 85.27° (MeOH), or [α]14D + 92.98°. Crystalline salts of the alkaloid have been prepared, e.g. the hydrochloride, m.p. 245-6°C (dec.); hydrobromide, m.p. 260-2°C (dec.) and the nitrate which crystallizes as the monohydrate, m.p. 220-2°C (dec. dry). Alkaline hydrolysis furnishes benzoic acid and hydroignavinol, C20H2S04N, m.p. 302°C.

Einzelnachweise

Ochiai et al., J. Pharm. Soc., Japan, 72, 816 (1952) Ochiai et al., ibid, 76, 550 (1956) Ochiai", Okamoto, Sasaki., ibid, 75,545 (1955) Ochiai et al., Chem. Pharm. Bull., 6,327 (1958) Ochiai et al., ibid, 8, 976 (1960) Pelletier., Tetrahedron, 14,103 (1961)

ignavine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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1357-76-2()Verwandte Suche:


  • ignavine
  • Hetisan-2α,3β,9,15β-tetrol 2-benzoate
  • Hetisan-2,3,9,15-tetrol, 2-benzoate, (2α,3β,15β)- (9CI)
  • 1357-76-2
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