Vinblastin

VINBLASTINE Struktur
865-21-4
CAS-Nr.
865-21-4
Bezeichnung:
Vinblastin
Englisch Name:
VINBLASTINE
Synonyma:
Rozevin;VINBLASTINE;Vincoblastine;Vincaleucoblastin;Vinblastine (7CI);Vincaleucoblastine;VINBLASTINE 94% BP98;VINBLASTINE SULFATE(RG);Vincristine EP Impurity H;Vinblastine, Vincaleukoblastine
CBNumber:
CB8201955
Summenformel:
C46H58N4O9
Molgewicht:
810.99
MOL-Datei:
865-21-4.mol

Vinblastin Eigenschaften

Schmelzpunkt:
211-216°
alpha 
D23 -32° (c = 0.88 in methanol)
Siedepunkt:
755.65°C (rough estimate)
Dichte
1.1325 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
Löslichkeit
Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol
Aggregatzustand
Solid
pka
5.4, 7.4(at 25℃)
Farbe
Yellow
EPA chemische Informationen
Vinblastine (865-21-4)

Sicherheit

RIDADR  1544
HazardClass  6.1(a)
PackingGroup  II
Giftige Stoffe Daten 865-21-4(Hazardous Substances Data)
Toxizität LD50 intraperitoneal in mouse: 3120ug/kg

Vinblastin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

An alkaloid derived from the periwinkle, Catharanthus roseus (formerly Vinca rosea) used as an antitumor drug in the treatment of Hodgkins lymphoma and other cancers. It binds to the microtubule subunit, tubulin, at a site distinct from that of colchicine and podophyllotoxin. This binding is reversible, temperature dependent and rapid, and results in large tubulin aggregates of highly ordered structure (vinblastine paracrystals).

Physikalische Eigenschaften

Appearance: needlelike crystals were produced when recrystallized by methanol. Solubility: soluble in chloroform, acetone, and ethanol. Melting point: 211– 216?°C.?Sulfate melting point of vinblastine is 284–285?°C; hydrochloric acid melting point of vinblastine is 244–246?°C (decomposes). Specific optical rotation: +42°.

Verwenden

Vinblastine is used for severe lymphoblastic leukemia, Hodgkin’s disease, nonHodgkin’s lymphoma, neuroblastoma, sarcoma, and other cancerous diseases.

Indications

It was recorded in the Pharmacopoeia of the People’s Republic of China (2015), the British Pharmacopoeia (2017), the United States Pharmacopeia (40), the Japanese Pharmacopoeia (17th ed.), the European Pharmacopoeia (9th ed.), and The International Pharmacopoeia (5th ed.).
Vinblastine sulfate injection is used as the first-line therapy to treat Hodgkin lymphoma, lymphocytic leukemia, testis tumor, and choriocarcinoma intravenously in clinical practice generally according to ABVD methods (Adriamycin, bleomycin, vinblastine, and dacarbazine).

Mechanism of action

Vinblastine suppresses cell growth during metaphase, affects amino acid metabolism, in particular at the level of including glutamine acid into the citric acid cycle and preventing it from transformation into urea, and it also inhibits protein and nucleic acid synthesis.

Pharmakokinetik

Leukopenia is the dose-limiting side effect, and dose reductions are warranted in patients with serum bilirubin levels greater than 3 mg/dL. The drug-related impact on erythrocyte and thrombocyte levels usually is insignificant. Like vincristine, it is administered as an IV bolus or infusion. The initial elimination half-life of 3.7 minutes is similar to vincristine, but the 24.8-hour terminal half-life is significantly shorter.

Clinical Use

In addition to the hematologic indications that it shares with vincristine, vinblastine sulfate has found utility in the treatment of advanced testicular carcinoma (often in combination with bleomycin), advanced mycosis fungoides, Kaposi's sarcoma, and histiocytosis X.

Vinblastin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Vinblastin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 222)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 3000 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

865-21-4(Vinblastin)Verwandte Suche:


  • VINBLASTINE 94% BP98
  • VINBLASTINE
  • VINBLASTINE SULFATE(RG)
  • [3aR-[3aa,4b,5b,5ab,9(3R*,5S*,7R*,9S*),10bR*,13aa]]-Methyl 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino[8,1-cd]carbazole-5-carboxylate
  • 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
  • 1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, [3aR-[3aa,4b,5b,5ab,9(3R*,5S*,7R*,9S*),10bR*,13aa]]-
  • 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
  • Rozevin
  • Vinblastine (7CI)
  • Vincaleucoblastin
  • Vincaleucoblastine
  • Vincaleukoblastine (6CI, 8CI, 9CI)
  • Vinblastine (base and/or unspecified salts)
  • Vinblastine, Vincaleukoblastine
  • Vinblastine,Vincaleucoblastine,Catharanthine
  • Vincoblastine
  • 1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(Methoxycarbonyl)-2H-3,7-Methanoazacycloundecino[5,4-b]in
  • Vincristine EP Impurity H
  • Vincristine Impurity 8(Vincristine EP Impurity H)
  • Vinblastine-d3 DISCONTINUED. Please see V314002
  • vincaleukoblastine(vinblastine)
  • *Codeine Phosphate Impurity 2 (Codeine Phosphate EP Impurity B)(Morphine)
  • (3aR,3a1R,4R,5S,5aR,10bR)-Methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate
  • 865-21-4
  • C46H58N4O9
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
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