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Ketotifen

KETOTIFEN Struktur
34580-13-7
CAS-Nr.
34580-13-7
Bezeichnung:
Ketotifen
Englisch Name:
KETOTIFEN
Synonyma:
hc20-511;HC 20-511;KETOTIFEN;Ketotifeno;idinylidene)-;hiophen-10-one;Ketotifen base;KETOTIFENFUMARATC;Ketotifen Fumaratic;Ketotifen Free Base
CBNumber:
CB9249738
Summenformel:
C19H19NOS
Molgewicht:
309.43
MOL-Datei:
34580-13-7.mol
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Ketotifen Eigenschaften

Schmelzpunkt:
152-153℃
Siedepunkt:
488.9±45.0 °C(Predicted)
Dichte
1.236
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
Löslichkeit
DMSO (Slightly, Heated), Methanol (Slightly)
pka
8.84±0.20(Predicted)
Aggregatzustand
Solid
Farbe
Light Yellow to Orange
InChI
InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3
InChIKey
ZCVMWBYGMWKGHF-UHFFFAOYSA-N
SMILES
C12C(=O)CC3=CC=CC=C3/C(=C3/CCN(C)CC/3)/C=1C=CS2
EPA chemische Informationen
Ketotifen (34580-13-7)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  29349990
Giftige Stoffe Daten 34580-13-7(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Ketotifen Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Ketotifen is an intermediate in the synthesis of Ketotifen N-Oxide Hydrochloride (K315410), which is a metabolite of Ketotifen (K315100) in humans; formed by human liver microsome. For the free base, see K315115.

Allgemeine Beschreibung

Crystals (from ethyl acetate).

Brandgefahr

Flash point data for KETOTIFEN are not available. KETOTIFEN is probably combustible.

Clinical Use

Ketotifen is a potent, selective H1 antihistamine that also prevents release of transmitters from mast cells. It is approved in the United States for topical use to prevent itching of the eye because of allergic conjunctivitis, It is used as a systemic antiallergy agent in several countries outside the United States for the treatment of seasonal allergic rhinitis, hay fever, and asthma. Being structurally analogous to the cyproheptadine-like antihistamines, differences in activity of the two enantiomers (atropisomers) has been noted, being approximately six- to seven-fold in ligand displacement and rodent-based assays. Ketotifen has been shown to stabilize mast cells and to inhibit degranulation of eosinophils. Like olopatadine, it has been shown to interact with model membranes, stabilizing them by interaction with phospholipids monolayers.

Ketotifen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Magnesium Hydrogenchlorid 4-Chloropiperidine hydrochloride 10-METHOXY-4H-BENZO[4,5]CYCLOHEPTA[1,2-B]THIOPHEN-4-ONE

Downstream Produkte

9,10-Dioxo Ketotifen

Ketotifen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 78)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
QINGDAO HONG JIN CHEMCIAL CO.,LTD.
532-83657313
hjt@hong-jin.com China 228 58
Wuhan Cell Pharmaceutical Co., Ltd
+86-13129979210 +86-13129979210
 sales@cellwh.com China 376 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49391 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289
 contact@trustwe.com China 5738 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671
sales@tnjchem.com China 34572 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665
 dominicguo@gk-bio.com CHINA 9427 58
Alfa Chemistry 		+1-5166625404
Info@alfa-chemistry.com United States 21317 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24738 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58

34580-13-7(Ketotifen)Verwandte Suche:

4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat Pizotifen Ketotifen
  • KETOTIFEN
  • 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piper
  • 4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
  • 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-10h-benzo(4,5)cyclohepta(1,2-b)t
  • 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one
  • 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
  • HC 20-511
  • hc20-511
  • hiophen-10-one
  • idinylidene)-
  • Ketotifen Fumaratic
  • KETOTIFENFUMARATC
  • 4-(1-Methyl-4-piperidinylidene)-4H-benzo[4,5]cyclohepta[1,2-d]thiophene-10(9H)-one
  • 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
  • Ketotifen base
  • Ketotifeno
  • 4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one
  • Ketotifen Free Base
  • 34580-13-7
  • C19H19NOS
  • API's
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