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ChemicalBook >> CAS DataBase List >>6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Structure
6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride structure
CAS No.
181632-25-7
Chemical Name:
6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride
Synonyms
CS-602;SB 242084;SB-242084/SB242084;dihydrochloride hydrate;SB 242084 Dihydrochloride Hydrate;SB242084 hydrate dihydrochloride;SB 242084 Hydrochloride - CAS 181632-25-7 - Calbiochem;6-CHLORO-2,3-DIHYDRO-5-METHYL-N-[6-[(2-METHYL-3-PYRIDINYL)OXY];6-chloro-5-Methyl-N-(6-(2-Methylpyridin-3-yloxy)pyridin-3-yl)indoline-1-carboxaMide;6-Chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide dihydroc
CBNumber:
CB02102836
Molecular Formula:
C21H19ClN4O2
Molecular Weight:
394.85
MDL Number:
MFCD02684417
MOL File:
181632-25-7.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:12
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6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Properties

Melting point 181-183℃
Boiling point 620.1±55.0 °C(Predicted)
Density 1.362±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
pka 12.47±0.20(Predicted)
form powder
color white to beige
InChIKey GCMNSEILNIPNSX-UHFFFAOYSA-N
FDA UNII 9FEE9A2U4Z

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5.06417 SB 242084 Hydrochloride - CAS 181632-25-7 - Calbiochem 181632-25-7 10mg $196 2023-06-20 Buy
Sigma-Aldrich S8061 SB 242084 dihydrochloride hydrate ≥98% (HPLC), powder 181632-25-7 5mg $949 2022-05-15 Buy
Sigma-Aldrich S8061 SB 242084 dihydrochloride hydrate ≥98% (HPLC), powder 181632-25-7 25mg $3280 2022-05-15 Buy
Tocris 2901 SB242084 ≥99%(HPLC) 181632-25-7 50 $942 2021-12-16 Buy
Tocris 2901 SB242084 ≥99%(HPLC) 181632-25-7 10 $225 2021-12-16 Buy
Product number Packaging Price Buy
5.06417 10mg $196 Buy
S8061 5mg $949 Buy
S8061 25mg $3280 Buy
2901 50 $942 Buy
2901 10 $225 Buy

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB 242084 displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors.SB 242084 os a brain penetrant; exerts anxiolytic-like activity.

Definition

ChEBI: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator.

Biological Activity

5-HT 2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT 2A and 5-HT 2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.

Biochem/physiol Actions

SB 242084 is a potent and selective antagonist of 5-HT2C receptor. It increases the basal activity of dopaminergic neurons and affects the behavioral responses mediated by 5-HT2C such as mesolimbic neuron activity and food intake.3,4,5

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride Suppliers

Global( 76)Suppliers
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HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
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Supplier Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
LEAPCHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Yunpun industrial Co.,Ltd 58
J & K SCIENTIFIC LTD. 76

181632-25-7(6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride)Related Search:

N-Methylaniline 2-Methylaminoethanol N-Methyl pyrrole N-Methylbenzamide N-Methyldiethanolamine
6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride 1-(3-CHLORO-4-METHYLPHENYL)-3-METHYLUREA 1-(3-CHLORO-4-METHYLPHENYL)UREA 6-CHLORO-2,3-DIHYDRO-1H-INDOLE 6-(3-PYRIDYLOXY)PYRIDIN-3-AMINE
5-Chloro-2-methylphenylurea 6-CHLORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE 6-Chloro-5-methylindoline

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6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride 6-Chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide dihydroc SB242084 hydrate dihydrochloride 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamidedihydrochloride SB 242084 SB-242084/SB242084 6-Chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide dihydrochlo 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride hydrate 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline dihydrochloride hydrate 6-Chloro-2,3-dihydro-5-Methyl-N-[6-[(2-Methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxaMide Dihydrochloride Hydrate SB 242084 Dihydrochloride Hydrate 6-CHLORO-2,3-DIHYDRO-5-METHYL-N-[6-[(2-METHYL-3-PYRIDINYL)OXY] dihydrochloride hydrate 6-chloro-5-Methyl-N-(6-(2-Methylpyridin-3-yloxy)pyridin-3-yl)indoline-1-carboxaMide dihydrochloride 6-chloro-5-Methyl-N-(6-(2-Methylpyridin-3-yloxy)pyridin-3-yl)indoline-1-carboxaMide 1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]- SB 242084 Hydrochloride - CAS 181632-25-7 - Calbiochem CS-602 6-chloro-5-methyl-N-{6-[(2-methylpyridin-3-yl)oxy] pyridin-3-yl}-2,3-dihydro-1H-indole-1-carboxamide 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride Serotonin Receptor,SB 242084,inhibit,5-HT Receptor,Inhibitor,SB-242084,5-hydroxytryptamine Receptor,SB242084 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyami 181632-25-7 C21H19ClN4O22HCl